| http://purl.uniprot.org/citations/20718664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20718664 | http://www.w3.org/2000/01/rdf-schema#comment | "Donor-reactive CD4(+)memory T cells threaten the survival of transplanted organs. In this study, we used anti-CD44 monoclonal antibody (mAb) to inhibit adoptively transferred B6-reactive CD4(+)memory T cells (BALB/c origin) and to induce tolerance of B6 hearts in nude mice. The median survival time (MST) of the grafts was 6 days in the isotype group, and more than 100 days in the group treated with 8 doses of anti-CD44 at four-day intervals. Histological analysis revealed that the mean rejection level was Grade 3 in the isotype group, and Grade 0 or 1 in the multi-dose anti-CD44 treatment group. Compared with the isotype group, the multiply treated anti-CD44 group had significantly decreased IL-2 and IFN-γ expressions, while IL-10 and TGF-β were increased in the serum and the graft. Foxp3 in the graft was also increased. These data demonstrate that alloreactive CD4(+) memory T cells mediate the destruction of allografts, and the adhesion molecule CD44 plays an important role in this course. Anti-CD44 mAb may promote the reduction of CD4(+)memory T cells and the production of regulatory T cells (Tregs). Furthermore, Tregs are maintained at a certain level while suppressing cellular immunity and inducing the grafts long-term survival in transplant recipients."xsd:string |
| http://purl.uniprot.org/citations/20718664 | http://purl.org/dc/terms/identifier | "doi:10.3109/08820139.2010.497833"xsd:string |
| http://purl.uniprot.org/citations/20718664 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/20718664 | http://purl.uniprot.org/core/author | "Qi Z."xsd:string |
| http://purl.uniprot.org/citations/20718664 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/20718664 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/20718664 | http://purl.uniprot.org/core/author | "Xie B."xsd:string |
| http://purl.uniprot.org/citations/20718664 | http://purl.uniprot.org/core/author | "Shao W."xsd:string |
| http://purl.uniprot.org/citations/20718664 | http://purl.uniprot.org/core/author | "Lan T."xsd:string |
| http://purl.uniprot.org/citations/20718664 | http://purl.uniprot.org/core/author | "Thorlacius H."xsd:string |
| http://purl.uniprot.org/citations/20718664 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20718664 | http://purl.uniprot.org/core/name | "Immunol Invest"xsd:string |
| http://purl.uniprot.org/citations/20718664 | http://purl.uniprot.org/core/pages | "807-819"xsd:string |
| http://purl.uniprot.org/citations/20718664 | http://purl.uniprot.org/core/title | "Anti-CD44 monoclonal antibody inhibits heart transplant rejection mediated by alloantigen-primed CD4(+) memory T cells in nude mice."xsd:string |
| http://purl.uniprot.org/citations/20718664 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/20718664 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20718664 |
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| http://purl.uniprot.org/uniprot/#_A2APM4-mappedCitation-20718664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20718664 |
| http://purl.uniprot.org/uniprot/#_Q3UNN2-mappedCitation-20718664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20718664 |
| http://purl.uniprot.org/uniprot/#_Q3U8S1-mappedCitation-20718664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20718664 |