| http://purl.uniprot.org/citations/20720508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20720508 | http://www.w3.org/2000/01/rdf-schema#comment | "Motor dysfunction, cognitive impairment, and regional cortical atrophy indicate cerebral cortical involvement in Huntington disease (HD). To address the hypothesis that abnormal corticostriatal connectivity arises from polyglutamine-related alterations in cortical gene expression, we isolated layer 5 cortical neurons by laser-capture microdissection and analyzed transcriptome-wide mRNA changes in them. Enrichment of transcription factor mRNAs including foxp2, tbr1, and neuroD6, and neurotransmission- and plasticity-related RNAs including sema5A, pclo, ntrk2, cntn1, and Lin7b were observed. Layer 5 motor cortex neurons of transgenic R6/2 HD mice also demonstrated numerous transcriptomic changes, including decreased expression of mRNAs encoding the Lin7 homolog b ([Lin7b] also known as veli-2 and mals2). Decreases in LIN7B and CNTN1 RNAs were also detected in human HD layer 5 motor cortex neurons. Lin7 homolog b, a scaffold protein implicated in synaptic plasticity, neurite outgrowth, and cellular polarity, was decreased at the protein level in layer 5 cortical neurons in R6/2 mice and human HD brains. Decreases in Lin7b and Lin7a mRNAs were detected in R6/2 cortex as early as 6 weeks of age, suggesting that this is an early pathogenetic event. Thus, decreased cortical LIN7 expression may contribute to abnormal corticostriatal connectivity in HD."xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.org/dc/terms/identifier | "doi:10.1097/nen.0b013e3181ed7a41"xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/author | "Kuhn A."xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/author | "Friedrich B."xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/author | "Gokce O."xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/author | "Faull R.L."xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/author | "Luthi-Carter R."xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/author | "Dunah A.W."xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/author | "Taylor D.M."xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/author | "Young A.B."xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/author | "Lindenberg K.S."xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/author | "Orlando L.R."xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/author | "Kama J.A."xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/author | "Zucker B."xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/author | "Weiller C."xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/author | "Lambeck J."xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/author | "Thu D."xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/name | "J Neuropathol Exp Neurol"xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/pages | "880-895"xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/title | "Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease."xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://purl.uniprot.org/core/volume | "69"xsd:string |
| http://purl.uniprot.org/citations/20720508 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20720508 |
| http://purl.uniprot.org/citations/20720508 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20720508 |