| http://purl.uniprot.org/citations/20724450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20724450 | http://www.w3.org/2000/01/rdf-schema#comment | "Heart formation requires the fusion of bilateral cardiomyocyte populations as they move towards the embryonic midline. The bHLH transcription factor Hand2 is essential for cardiac fusion; however, the effector genes that execute this function of Hand2 are unknown. Here, we provide in zebrafish the first evidence for a downstream component of the Hand2 pathway that mediates cardiac morphogenesis. Although hand2 is expressed in cardiomyocytes, mosaic analysis demonstrates that it plays a non-autonomous role in regulating cardiomyocyte movement. Gene expression profiles reveal heightened expression of fibronectin 1 (fn1) in hand2 mutant embryos. Reciprocally, overexpression of hand2 leads to decreased Fibronectin levels. Furthermore, reduction of fn1 function enables rescue of cardiac fusion in hand2 mutants: bilateral cardiomyocyte populations merge and exhibit improved tissue architecture, albeit without major changes in apicobasal polarity. Together, our data provide a novel example of a tissue creating a favorable environment for its morphogenesis: the Hand2 pathway establishes an appropriate environment for cardiac fusion through negative modulation of Fn1 levels."xsd:string |
| http://purl.uniprot.org/citations/20724450 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.052225"xsd:string |
| http://purl.uniprot.org/citations/20724450 | http://purl.uniprot.org/core/author | "Yelon D."xsd:string |
| http://purl.uniprot.org/citations/20724450 | http://purl.uniprot.org/core/author | "Garavito-Aguilar Z.V."xsd:string |
| http://purl.uniprot.org/citations/20724450 | http://purl.uniprot.org/core/author | "Riley H.E."xsd:string |
| http://purl.uniprot.org/citations/20724450 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20724450 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/20724450 | http://purl.uniprot.org/core/pages | "3215-3220"xsd:string |
| http://purl.uniprot.org/citations/20724450 | http://purl.uniprot.org/core/title | "Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function."xsd:string |
| http://purl.uniprot.org/citations/20724450 | http://purl.uniprot.org/core/volume | "137"xsd:string |
| http://purl.uniprot.org/citations/20724450 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20724450 |
| http://purl.uniprot.org/citations/20724450 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20724450 |
| http://purl.uniprot.org/uniprot/#_B0S602-mappedCitation-20724450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20724450 |
| http://purl.uniprot.org/uniprot/#_A0A8M3B2G8-mappedCitation-20724450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20724450 |
| http://purl.uniprot.org/uniprot/#_A2BDM6-mappedCitation-20724450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20724450 |
| http://purl.uniprot.org/uniprot/#_P57102-mappedCitation-20724450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20724450 |
| http://purl.uniprot.org/uniprot/P57102 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20724450 |
| http://purl.uniprot.org/uniprot/A2BDM6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20724450 |
| http://purl.uniprot.org/uniprot/A0A8M3B2G8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20724450 |
| http://purl.uniprot.org/uniprot/B0S602 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20724450 |