Results

RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/20726226http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20726226http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To observe the effect of Polypeptide from Chlamys farreri (PCF) on expression levels of Fas and c-fos in HaCaT cells after ultraviolet A (UVA) radiation, and investigate the molecular mechanism of PCF protecting against UVA-induced damage in HaCaT cells.

Methods

HaCaT cells were divided into five groups: control group, UVA model group, 5.69 mmol/L PCF group, 2.84 mmol/L PCF group, and 1.42 mmol/L PCF group. Expression levels of Fas and c-fos mRNA was assayed by PCR. Western blot analysis was used to determine the protein levels of Fas and c-fos.

Results

After UVA exposure, Fas and c-fos expression increased significantly (P < 0.01). 1.42 - 5.69 mmol/L PCF inhibited UVA-induced mRNA and protein expressions of Fas and c-fos in HaCaT cells in dose-dependent manner (P < 0.05).

Conclusion

PCF could attenuate UVA-induced Fas and c-fos expression, which may attribute to its protective effect against UVA-induced damage in HaCaT cells."xsd:string
http://purl.uniprot.org/citations/20726226http://purl.uniprot.org/core/author"Dong X."xsd:string
http://purl.uniprot.org/citations/20726226http://purl.uniprot.org/core/author"Li J."xsd:string
http://purl.uniprot.org/citations/20726226http://purl.uniprot.org/core/author"Li N."xsd:string
http://purl.uniprot.org/citations/20726226http://purl.uniprot.org/core/author"Wang C."xsd:string
http://purl.uniprot.org/citations/20726226http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20726226http://purl.uniprot.org/core/name"Wei Sheng Yan Jiu"xsd:string
http://purl.uniprot.org/citations/20726226http://purl.uniprot.org/core/pages"416-419"xsd:string
http://purl.uniprot.org/citations/20726226http://purl.uniprot.org/core/title"[Effect of polypeptide from Chlamys farreri on ultraviolet A-induced Fas and c-fos expression in HaCaT cells]."xsd:string
http://purl.uniprot.org/citations/20726226http://purl.uniprot.org/core/volume"39"xsd:string
http://purl.uniprot.org/citations/20726226http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20726226
http://purl.uniprot.org/citations/20726226http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20726226
http://purl.uniprot.org/uniprot/#_P01100-mappedCitation-20726226http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20726226
http://purl.uniprot.org/uniprot/#_Q6FG41-mappedCitation-20726226http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20726226
http://purl.uniprot.org/uniprot/#_Q76MY9-mappedCitation-20726226http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20726226
http://purl.uniprot.org/uniprot/#_Q76MZ0-mappedCitation-20726226http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20726226
http://purl.uniprot.org/uniprot/Q76MZ0http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20726226
http://purl.uniprot.org/uniprot/P01100http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20726226
http://purl.uniprot.org/uniprot/Q6FG41http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20726226
http://purl.uniprot.org/uniprot/Q76MY9http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20726226