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| http://purl.uniprot.org/citations/20729845 | http://www.w3.org/2000/01/rdf-schema#comment | "Selective expression of retinal cone opsin genes is essential for color vision, but the mechanism mediating this process is poorly understood. Both vertebrate rod and medium wavelength-sensitive (M) cone photoreceptors differentiate by repression of a short wavelength-sensitive (S) cone differentiation program. We found that Pias3 acts in mouse cone photoreceptors to activate expression of M opsin and repress expression of S opsin, with the transcription factors Trbeta2 and Rxrgamma mediating preferential expression of Pias3 in M cones. Finally, we observed that Pias3 directly regulated M and S cone opsin expression by modulating the cone-enriched transcription factors Rxrgamma, Roralpha and Trbeta1. Our results indicate that Pias3-dependent SUMOylation of photoreceptor-specific transcription factors is a common mechanism that controls both rod and cone photoreceptor subtype specification, regulating distinct molecular targets in the two cell types."xsd:string |
| http://purl.uniprot.org/citations/20729845 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.2618"xsd:string |
| http://purl.uniprot.org/citations/20729845 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/20729845 | http://purl.uniprot.org/core/author | "Blackshaw S."xsd:string |
| http://purl.uniprot.org/citations/20729845 | http://purl.uniprot.org/core/author | "Onishi A."xsd:string |
| http://purl.uniprot.org/citations/20729845 | http://purl.uniprot.org/core/author | "Peng G.H."xsd:string |
| http://purl.uniprot.org/citations/20729845 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20729845 | http://purl.uniprot.org/core/name | "Nat Neurosci"xsd:string |
| http://purl.uniprot.org/citations/20729845 | http://purl.uniprot.org/core/pages | "1059-1065"xsd:string |
| http://purl.uniprot.org/citations/20729845 | http://purl.uniprot.org/core/title | "Pias3-dependent SUMOylation controls mammalian cone photoreceptor differentiation."xsd:string |
| http://purl.uniprot.org/citations/20729845 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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