| http://purl.uniprot.org/citations/20730098 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20730098 | http://www.w3.org/2000/01/rdf-schema#comment | "LAIR-1 (Leukocyte Associated Ig-like Receptor -1) is a collagen receptor that functions as an inhibitory receptor on immune cells. It has a soluble family member, LAIR-2, that also binds collagen and can interfere with LAIR-1/collagen interactions. Collagen is a main initiator for platelet adhesion and aggregation. Here, we explored the potential of soluble LAIR proteins to inhibit thrombus formation in vitro. LAIR-2/Fc but not LAIR-1/Fc inhibited collagen-induced platelet aggregation. In addition, LAIR-2/Fc also interfered with platelet adhesion to collagen at low shear rate (300 s(-1); IC(50) = 18 microg/ml) and high shear rate (1500 s(-1); IC(50) = 30 microg/ml). Additional experiments revealed that LAIR-2/Fc leaves interactions between collagen and alpha2beta1 unaffected, but efficiently prevents binding of collagen to Glycoprotein VI and von Willebrand factor. Thus, LAIR-2/Fc has the capacity to interfere with platelet-collagen interactions mediated by Glycoprotein VI and the VWF/Glycoprotein Ib axis."xsd:string |
| http://purl.uniprot.org/citations/20730098 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0012174"xsd:string |
| http://purl.uniprot.org/citations/20730098 | http://purl.uniprot.org/core/author | "Denis C.V."xsd:string |
| http://purl.uniprot.org/citations/20730098 | http://purl.uniprot.org/core/author | "Lenting P.J."xsd:string |
| http://purl.uniprot.org/citations/20730098 | http://purl.uniprot.org/core/author | "Meyaard L."xsd:string |
| http://purl.uniprot.org/citations/20730098 | http://purl.uniprot.org/core/author | "Westerlaken G.H."xsd:string |
| http://purl.uniprot.org/citations/20730098 | http://purl.uniprot.org/core/author | "Akkerman J.W."xsd:string |
| http://purl.uniprot.org/citations/20730098 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20730098 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/20730098 | http://purl.uniprot.org/core/pages | "e12174"xsd:string |
| http://purl.uniprot.org/citations/20730098 | http://purl.uniprot.org/core/title | "Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member."xsd:string |
| http://purl.uniprot.org/citations/20730098 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/20730098 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20730098 |
| http://purl.uniprot.org/citations/20730098 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20730098 |
| http://purl.uniprot.org/uniprot/#_P02452-mappedCitation-20730098 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20730098 |
| http://purl.uniprot.org/uniprot/#_P08123-mappedCitation-20730098 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20730098 |
| http://purl.uniprot.org/uniprot/#_P02461-mappedCitation-20730098 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20730098 |
| http://purl.uniprot.org/uniprot/#_Q6ISS4-mappedCitation-20730098 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20730098 |
| http://purl.uniprot.org/uniprot/P02452 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20730098 |
| http://purl.uniprot.org/uniprot/P02461 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20730098 |
| http://purl.uniprot.org/uniprot/Q6ISS4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20730098 |
| http://purl.uniprot.org/uniprot/P08123 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20730098 |