| http://purl.uniprot.org/citations/20730551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20730551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20730551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/20730551 | http://www.w3.org/2000/01/rdf-schema#comment | "Plant cytochrome P450s are involved in the biosynthesis of various classes of secondary metabolites. To elucidate the biosynthesis of zerumbone, a sesquiterpenoid with multiple potential anticancer properties, a family of P450 genes expressed in rhizomes of Zingiber zerumbet Smith, were cloned using a PCR-based cloning strategy. After functional expression in yeast, one of these P450s was found to convert α-humulene into 8-hydroxy-α-humulene, a proposed intermediate of zerumbone biosynthesis. This P450 has been designated CYP71BA1, a new member of the CYP71 family. CYP71BA1 transcripts were detected almost exclusively in rhizomes and showed a similar expression pattern to ZSS1 transcripts during rhizome development. Coexpression of a gene cluster encoding four enzymes of the mevalonate pathway with CYP71BA1 and ZSS1 in Escherichia coli leads to the production of 8-hydroxy-α-humulene in the presence of mevalonate, suggesting the possibility of microbial production of this zerumbone intermediate from a relatively simple carbon source by metabolic engineering."xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-010-0506-4"xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-010-0506-4"xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/author | "Okamoto S."xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/author | "Okamoto S."xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/author | "Yu F."xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/author | "Yu F."xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/author | "Misawa N."xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/author | "Misawa N."xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/author | "Utsumi R."xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/author | "Utsumi R."xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/author | "Yamasaki K."xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/author | "Yamasaki K."xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/author | "Harada H."xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/author | "Harada H."xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/name | "Cell. Mol. Life Sci."xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/name | "Cell. Mol. Life Sci."xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/pages | "1033-1040"xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/pages | "1033-1040"xsd:string |
| http://purl.uniprot.org/citations/20730551 | http://purl.uniprot.org/core/title | "Zingiber zerumbet CYP71BA1 catalyzes the conversion of alpha-humulene to 8-hydroxy-alpha-humulene in zerumbone biosynthesis."xsd:string |