| http://purl.uniprot.org/citations/20732303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20732303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20732303 | http://www.w3.org/2000/01/rdf-schema#comment | "MKK4 activates both JNKs and p38s. We determined the crystal structures of human non-phosphorylated MKK4 kinase domain (npMKK4) complexed with AMP-PNP (npMKK4/AMP) and a ternary complex of npMKK4, AMP-PNP and p38α peptide (npMKK4/AMP/p38). These crystal structures revealed that the p38α peptide-bound npMKK4 at the allosteric site rather than at the putative substrate binding site and induced an auto-inhibition state. While the activation loop of the npMKK4/AMP complex was disordered, in the npMKK4/AMP/p38 complex it configured a long α-helix, which prevented substrate access to the active site and αC-helix movement to the active configuration of MKK4."xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2010.08.071"xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2010.08.071"xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/author | "Hamada K."xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/author | "Hamada K."xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/author | "Matsumoto T."xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/author | "Matsumoto T."xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/author | "Yokota K."xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/author | "Yokota K."xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/author | "Kinoshita T."xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/author | "Kinoshita T."xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/author | "Tada T."xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/author | "Tada T."xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/author | "Kirii Y."xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/author | "Kirii Y."xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/pages | "369-373"xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/pages | "369-373"xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/title | "Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state."xsd:string |
| http://purl.uniprot.org/citations/20732303 | http://purl.uniprot.org/core/title | "Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state."xsd:string |