| http://purl.uniprot.org/citations/20732370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20732370 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic obstructive pulmonary disease (COPD) may be related to chronic inflammation and immune-mediated conditions, and its pathogenesis involves T-cell activation and proliferation. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecules (CD80/CD86) genes are important mediators of T-cell activation in the immune response. The aim of this study was to investigate whether +2379G/C (rs17281995) and +1057G/A (rs1129055) in CD86 and -318C/T (rs5742909) and +49A/G (rs231775) in CTLA-4 genes single nucleotide polymorphisms (SNPs) are associated with COPD in a Chinese population. The four polymorphisms were identified in 396 COPD patients and 400 controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The frequency of the T allele of the -318C/T in CTLA-4 and the A allele of the +1057G/A in CD86 polymorphisms showed significant association with COPD when compared with controls (T allele: p < 0.0001; A allele: p = 0.009). Comparison of genotype frequencies showed that -318CT, +1057GA, and +1057AA genotype was overrepresented in the COPD group, respectively (-318CT: 50.8% vs 28.5%, p < 0.0001; +1057GA: 58.6% vs 54.2%, p = 0.002; +1057AA: 30.1% vs 25.8%, p = 0.002). However, we failed to find any association between the four SNPs and COPD when cases were classified by smoking status or clinical stages (p > 0.05). The results indicate that the polymorphisms of CTLA-4 (-318C/T) and CD86 (+1057G/A) may be important genetic factor associated with risk or protection for COPD in Chinese population."xsd:string |
| http://purl.uniprot.org/citations/20732370 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2010.08.007"xsd:string |
| http://purl.uniprot.org/citations/20732370 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/20732370 | http://purl.uniprot.org/core/author | "Xue H."xsd:string |
| http://purl.uniprot.org/citations/20732370 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/20732370 | http://purl.uniprot.org/core/author | "Zhang L.S."xsd:string |
| http://purl.uniprot.org/citations/20732370 | http://purl.uniprot.org/core/author | "Wang Y.Y."xsd:string |
| http://purl.uniprot.org/citations/20732370 | http://purl.uniprot.org/core/author | "Chen T.Y."xsd:string |
| http://purl.uniprot.org/citations/20732370 | http://purl.uniprot.org/core/author | "Pan X.M."xsd:string |
| http://purl.uniprot.org/citations/20732370 | http://purl.uniprot.org/core/author | "Liang W.B."xsd:string |
| http://purl.uniprot.org/citations/20732370 | http://purl.uniprot.org/core/author | "Gao L.B."xsd:string |
| http://purl.uniprot.org/citations/20732370 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20732370 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/20732370 | http://purl.uniprot.org/core/pages | "1141-1146"xsd:string |
| http://purl.uniprot.org/citations/20732370 | http://purl.uniprot.org/core/title | "CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease."xsd:string |
| http://purl.uniprot.org/citations/20732370 | http://purl.uniprot.org/core/volume | "71"xsd:string |
| http://purl.uniprot.org/citations/20732370 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20732370 |
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| http://purl.uniprot.org/uniprot/#_E9L3G3-mappedCitation-20732370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20732370 |
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| http://purl.uniprot.org/uniprot/#_P42081-mappedCitation-20732370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20732370 |