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http://purl.uniprot.org/citations/20732627http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20732627http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Although twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. Thus additional genomewide association studies (GWAS) are needed.

Method

We used case-control analyses of 896 cases with DSM-IV ADHD genotyped using the Affymetrix 5.0 array and 2,455 repository controls screened for psychotic and bipolar symptoms genotyped using Affymetrix 6.0 arrays. A consensus SNP set was imputed using BEAGLE 3.0, resulting in an analysis dataset of 1,033,244 SNPs. Data were analyzed using a generalized linear model.

Results

No genome-wide significant associations were found. The most significant results implicated the following genes: PRKG1, FLNC, TCERG1L, PPM1H, NXPH1, PPM1H, CDH13, HK1, and HKDC1.

Conclusions

The current analyses are a useful addition to the present literature and will make a valuable contribution to future meta-analyses. The candidate gene findings are consistent with a prior meta-analysis in suggesting that the effects of ADHD risk variants must, individually, be very small and/or include multiple rare alleles."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.org/dc/terms/identifier"doi:10.1016/j.jaac.2010.06.007"xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Nguyen T.T."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Meyer J."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Neale B.M."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Schafer H."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Daly M."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Gill M."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Ripke S."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Sergeant J."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Kent L."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Reif A."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Holmans P."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Walitza S."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Asherson P."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Hawi Z."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Faraone S.V."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Middleton F."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Warnke A."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Franke B."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Anney R.J."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Lesch K.P."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Romanos J."xsd:string
http://purl.uniprot.org/citations/20732627http://purl.uniprot.org/core/author"Freitag C."xsd:string
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