| http://purl.uniprot.org/citations/20733053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20733053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20733053 | http://www.w3.org/2000/01/rdf-schema#comment | "Postsynaptic density 95/discs large/zonus occludens-1 (PDZ) domain-interacting motifs, in addition to their well-established roles in protein scaffolding at the cell surface, are proposed to act as cis-acting determinants directing the molecular sorting of transmembrane cargo from endosomes to the plasma membrane. This hypothesis requires the existence of a specific trans-acting PDZ protein that mediates the proposed sorting operation in the endosome membrane. Here, we show that sorting nexin 27 (SNX27) is required for efficient PDZ-directed recycling of the beta(2)-adrenoreceptor (beta(2)AR) from early endosomes. SNX27 mediates this sorting function when expressed at endogenous levels, and its recycling activity requires both PDZ domain-dependent recognition of the beta(2)AR cytoplasmic tail and Phox homology (PX) domain-dependent association with the endosome membrane. These results identify a discrete role of SNX27 in PDZ-directed recycling of a physiologically important signaling receptor, and extend the concept of cargo-specific molecular sorting in the recycling pathway."xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201004060"xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201004060"xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/author | "Hong W."xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/author | "Hong W."xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/author | "Kortemme T."xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/author | "Kortemme T."xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/author | "Lei C."xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/author | "Lei C."xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/author | "von Zastrow M."xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/author | "von Zastrow M."xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/author | "Lauffer B.E."xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/author | "Lauffer B.E."xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/author | "Melero C."xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/author | "Melero C."xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/author | "Temkin P."xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/author | "Temkin P."xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/pages | "565-574"xsd:string |
| http://purl.uniprot.org/citations/20733053 | http://purl.uniprot.org/core/pages | "565-574"xsd:string |