| http://purl.uniprot.org/citations/20739295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20739295 | http://www.w3.org/2000/01/rdf-schema#comment | "Expansion of a polyglutamine (polyQ) tract in the Huntingtin (Htt) protein causes Huntington's disease (HD), a fatal inherited neurodegenerative disorder. Loss of the normal function of Htt is thought to be an important pathogenetic component of HD. However, the function of wild-type Htt is not well defined. Htt is thought to be a multifunctional protein that plays distinct roles in several biological processes, including synaptic transmission, intracellular transport and neuronal transcription. Here, we show with biochemical and live cell imaging studies that wild-type Htt stimulates the transport of nuclear factor κ light-chain-enhancer of activated B cells (NF-κB) out of dendritic spines (where NF-κB is activated by excitatory synaptic input) and supports a high level of active NF-κB in neuronal nuclei (where NF-κB stimulates the transcription of target genes). We show that this novel function of Htt is impaired by the polyQ expansion and thus may contribute to the etiology of HD."xsd:string |
| http://purl.uniprot.org/citations/20739295 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddq358"xsd:string |
| http://purl.uniprot.org/citations/20739295 | http://purl.uniprot.org/core/author | "Kennedy M.B."xsd:string |
| http://purl.uniprot.org/citations/20739295 | http://purl.uniprot.org/core/author | "Marcora E."xsd:string |
| http://purl.uniprot.org/citations/20739295 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20739295 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/20739295 | http://purl.uniprot.org/core/pages | "4373-4384"xsd:string |
| http://purl.uniprot.org/citations/20739295 | http://purl.uniprot.org/core/title | "The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-kappaB from the synapse to the nucleus."xsd:string |
| http://purl.uniprot.org/citations/20739295 | http://purl.uniprot.org/core/volume | "19"xsd:string |
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| http://purl.uniprot.org/uniprot/P51111#attribution-AF9659D6DB85BC35060C302CD2C10E31 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20739295 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K7F5-mappedCitation-20739295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20739295 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZQU2-mappedCitation-20739295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20739295 |
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| http://purl.uniprot.org/uniprot/#_A0A8I6A2E3-mappedCitation-20739295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20739295 |
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| http://purl.uniprot.org/uniprot/#_A0A8I5Y907-mappedCitation-20739295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20739295 |
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| http://purl.uniprot.org/uniprot/#_A0A8I5ZNM8-mappedCitation-20739295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20739295 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZP61-mappedCitation-20739295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20739295 |