| http://purl.uniprot.org/citations/20795791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20795791 | http://www.w3.org/2000/01/rdf-schema#comment | "Prokineticin-1 (PK1) has been identified as a mitogen-specific protein for the endothelium of steroidogenic glands. Here we report a novel function of PK1 in the regulation of multiple myeloma (MM) cells. PK1 activates multiple signals including mitogen-activated protein kinase (MAPK), PI3K-AKT, and Jak-STAT3, sphingosine kinase-1 (SPK1) in MM cells. Treatment of MM cells with PK1 causes a time- and dose-dependent phosphorylation of MAPK, AKT and STAT3 and upregulation of SPK1 expression and cellular activity. We also show that PK1 upregulates Mcl-1 expression in a time- and dose-dependent manner in human MM cell lines and in the cells of patients with MM. Pertussis toxin, a pan-PK1 receptor inhibitor, can block PK1-induced upregulation of Mcl-1, indicating it relates to a G-protein-coupled receptor. We also show that PK1 protects MM cells against apoptosis induced by starvation for fetal calf serum (FBS), or for FBS and IL-6. Taken together, PK1 activates multiple signaling pathways and, upregulates Mcl-1 expression, leading to proliferation and survival of MM cells."xsd:string |
| http://purl.uniprot.org/citations/20795791 | http://purl.org/dc/terms/identifier | "doi:10.3109/10428194.2010.512963"xsd:string |
| http://purl.uniprot.org/citations/20795791 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/20795791 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/20795791 | http://purl.uniprot.org/core/author | "Zhu H.Y."xsd:string |
| http://purl.uniprot.org/citations/20795791 | http://purl.uniprot.org/core/author | "Yang Y.F."xsd:string |
| http://purl.uniprot.org/citations/20795791 | http://purl.uniprot.org/core/author | "Li Q.F."xsd:string |
| http://purl.uniprot.org/citations/20795791 | http://purl.uniprot.org/core/author | "Wang L.S."xsd:string |
| http://purl.uniprot.org/citations/20795791 | http://purl.uniprot.org/core/author | "Wu C.T."xsd:string |
| http://purl.uniprot.org/citations/20795791 | http://purl.uniprot.org/core/author | "Xiao F.J."xsd:string |
| http://purl.uniprot.org/citations/20795791 | http://purl.uniprot.org/core/author | "Zhang Q.W."xsd:string |
| http://purl.uniprot.org/citations/20795791 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20795791 | http://purl.uniprot.org/core/name | "Leuk Lymphoma"xsd:string |
| http://purl.uniprot.org/citations/20795791 | http://purl.uniprot.org/core/pages | "1902-1912"xsd:string |
| http://purl.uniprot.org/citations/20795791 | http://purl.uniprot.org/core/title | "Prokineticin-1/endocrine gland-derived vascular endothelial growth factor is a survival factor for human multiple myeloma cells."xsd:string |
| http://purl.uniprot.org/citations/20795791 | http://purl.uniprot.org/core/volume | "51"xsd:string |
| http://purl.uniprot.org/citations/20795791 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20795791 |
| http://purl.uniprot.org/citations/20795791 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20795791 |
| http://purl.uniprot.org/uniprot/#_P58294-mappedCitation-20795791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20795791 |
| http://purl.uniprot.org/uniprot/#_Q8TCW9-mappedCitation-20795791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20795791 |
| http://purl.uniprot.org/uniprot/Q8TCW9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20795791 |
| http://purl.uniprot.org/uniprot/P58294 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20795791 |