| http://purl.uniprot.org/citations/20798234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20798234 | http://www.w3.org/2000/01/rdf-schema#comment | "Histone methylation is an important regulator of gene expression; its coordinated activity is critical in complex developmental processes such as hematopoiesis. Disruptor of telomere silencing 1-like (DOT1L) is a unique histone methyltransferase that specifically methylates histone H3 at lysine 79. We analyzed Dot1L-mutant mice to determine influence of this enzyme on embryonic hematopoiesis. Mutant mice developed more slowly than wild-type embryos and died between embryonic days 10.5 and 13.5, displaying a striking anemia, especially apparent in small vessels of the yolk sac. Further, a severe, selective defect in erythroid, but not myeloid, differentiation was observed. Erythroid progenitors failed to develop normally, showing retarded progression through the cell cycle, accumulation during G₀/G₁ stage, and marked increase in apoptosis in response to erythroid growth factors. GATA2, a factor essential for early erythropoiesis, was significantly reduced in Dot1L-deficient cells, whereas expression of PU.1, a transcription factor that inhibits erythropoiesis and promotes myelopoiesis, was increased. These data suggest a model whereby DOT1L-dependent lysine 79 of histone H3 methylation serves as a critical regulator of a differentiation switch during early hematopoiesis, regulating steady-state levels of GATA2 and PU.1 transcription, thus controlling numbers of circulating erythroid and myeloid cells."xsd:string |
| http://purl.uniprot.org/citations/20798234 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-03-276501"xsd:string |
| http://purl.uniprot.org/citations/20798234 | http://purl.uniprot.org/core/author | "Feng Y."xsd:string |
| http://purl.uniprot.org/citations/20798234 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/20798234 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/20798234 | http://purl.uniprot.org/core/author | "Fields T.A."xsd:string |
| http://purl.uniprot.org/citations/20798234 | http://purl.uniprot.org/core/author | "Vivian J.L."xsd:string |
| http://purl.uniprot.org/citations/20798234 | http://purl.uniprot.org/core/author | "Fields P.E."xsd:string |
| http://purl.uniprot.org/citations/20798234 | http://purl.uniprot.org/core/author | "Ortega M.M."xsd:string |
| http://purl.uniprot.org/citations/20798234 | http://purl.uniprot.org/core/author | "Jacob J.B."xsd:string |
| http://purl.uniprot.org/citations/20798234 | http://purl.uniprot.org/core/author | "Copeland J.N."xsd:string |
| http://purl.uniprot.org/citations/20798234 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20798234 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/20798234 | http://purl.uniprot.org/core/pages | "4483-4491"xsd:string |
| http://purl.uniprot.org/citations/20798234 | http://purl.uniprot.org/core/title | "Early mammalian erythropoiesis requires the Dot1L methyltransferase."xsd:string |
| http://purl.uniprot.org/citations/20798234 | http://purl.uniprot.org/core/volume | "116"xsd:string |
| http://purl.uniprot.org/citations/20798234 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20798234 |
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| http://purl.uniprot.org/uniprot/#_B1ARB3-mappedCitation-20798234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20798234 |
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| http://purl.uniprot.org/uniprot/#_F6SJX8-mappedCitation-20798234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20798234 |