| http://purl.uniprot.org/citations/20798282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20798282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20798282 | http://www.w3.org/2000/01/rdf-schema#comment | "Presynaptic nerve terminals release neurotransmitters repeatedly, often at high frequency, and in relative isolation from neuronal cell bodies. Repeated release requires cycles of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-complex assembly and disassembly, with continuous generation of reactive SNARE-protein intermediates. Although many forms of neurodegeneration initiate presynaptically, only few pathogenic mechanisms are known, and the functions of presynaptic proteins linked to neurodegeneration, such as α-synuclein, remain unclear. Here, we show that maintenance of continuous presynaptic SNARE-complex assembly required a nonclassical chaperone activity mediated by synucleins. Specifically, α-synuclein directly bound to the SNARE-protein synaptobrevin-2/vesicle-associated membrane protein 2 (VAMP2) and promoted SNARE-complex assembly. Moreover, triple-knockout mice lacking synucleins developed age-dependent neurological impairments, exhibited decreased SNARE-complex assembly, and died prematurely. Thus, synucleins may function to sustain normal SNARE-complex assembly in a presynaptic terminal during aging."xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1195227"xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1195227"xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/author | "Suedhof T.C."xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/author | "Suedhof T.C."xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/author | "Sharma M."xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/author | "Sharma M."xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/author | "Burre J."xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/author | "Burre J."xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/author | "Tsetsenis T."xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/author | "Tsetsenis T."xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/author | "Etherton M.R."xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/author | "Etherton M.R."xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/author | "Buchman V."xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/author | "Buchman V."xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/pages | "1663-1667"xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/pages | "1663-1667"xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/title | "Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro."xsd:string |
| http://purl.uniprot.org/citations/20798282 | http://purl.uniprot.org/core/title | "Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro."xsd:string |