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http://purl.uniprot.org/citations/20800922http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20800922http://www.w3.org/2000/01/rdf-schema#comment"

Background & aims

The adaptive immune response against hepatitis C virus (HCV) is significantly shaped by the host's composition of HLA-alleles with the consequence that the HLA phenotype is a critical determinant of viral evolution during adaptive immune pressure. In the present study, we aimed to identify associations of HLA class I alleles with HCV subtypes 1a and 1b genetic variants.

Methods

The association between HCV genetic variants and specific HLA-alleles was investigated in a cohort of 159 patients with chronic HCV genotypes 1a- and 1b-infection who were treated with pegylated interferon-alfa 2b and ribavirin in a prospective controlled trial for 48 weeks by direct sequencing of the genes encoding the HCV proteins E2, NS3, and NS5B and by HLA class I-genotyping of patients. HCV genetic variants were associated with specific HLA-alleles and the binding strength of accordant amino acid sequences to the corresponding HLA-allele was assessed by using the SYFPEITHI-algorithm.

Results

Overall, associations between HLA class I alleles and HCV sequence variation were rare. Five unknown HLA class I-associated viral genetic variations were identified, which in part affected the binding of predicted HCV CD8+ T cell epitopes to the respective HLA-allele. In addition, different patterns of HLA class I-allele/HCV sequence associations between the two subtypes were observed.

Conclusions

We identified several unknown HLA class I-restricted HCV variants which in part impair binding to predicted HCV CD8+ T cell epitopes with remarkable differences between HCV subtypes 1a and 1b quasispecies."xsd:string
http://purl.uniprot.org/citations/20800922http://purl.org/dc/terms/identifier"doi:10.1016/j.jhep.2010.06.011"xsd:string
http://purl.uniprot.org/citations/20800922http://purl.uniprot.org/core/author"Berg T."xsd:string
http://purl.uniprot.org/citations/20800922http://purl.uniprot.org/core/author"Lengauer T."xsd:string
http://purl.uniprot.org/citations/20800922http://purl.uniprot.org/core/author"Roomp K."xsd:string
http://purl.uniprot.org/citations/20800922http://purl.uniprot.org/core/author"Sarrazin C."xsd:string
http://purl.uniprot.org/citations/20800922http://purl.uniprot.org/core/author"Zeuzem S."xsd:string
http://purl.uniprot.org/citations/20800922http://purl.uniprot.org/core/author"Nattermann J."xsd:string
http://purl.uniprot.org/citations/20800922http://purl.uniprot.org/core/author"Spengler U."xsd:string
http://purl.uniprot.org/citations/20800922http://purl.uniprot.org/core/author"Weich V."xsd:string
http://purl.uniprot.org/citations/20800922http://purl.uniprot.org/core/author"Michalk M."xsd:string
http://purl.uniprot.org/citations/20800922http://purl.uniprot.org/core/author"Dragan A."xsd:string
http://purl.uniprot.org/citations/20800922http://purl.uniprot.org/core/author"Lange C.M."xsd:string
http://purl.uniprot.org/citations/20800922http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20800922http://purl.uniprot.org/core/name"J Hepatol"xsd:string
http://purl.uniprot.org/citations/20800922http://purl.uniprot.org/core/pages"1022-1028"xsd:string
http://purl.uniprot.org/citations/20800922http://purl.uniprot.org/core/title"HLA class I allele associations with HCV genetic variants in patients with chronic HCV genotypes 1a or 1b infection."xsd:string
http://purl.uniprot.org/citations/20800922http://purl.uniprot.org/core/volume"53"xsd:string
http://purl.uniprot.org/citations/20800922http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20800922
http://purl.uniprot.org/citations/20800922http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20800922
http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-20800922http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20800922
http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-20800922http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20800922
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http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-20800922http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20800922
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