| http://purl.uniprot.org/citations/20802483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20802483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20802483 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 1β (IL-1β) is a key orchestrator of inflammation and host defense that exerts its effects through IL-1 receptor type I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). How IL-1RAcP is recruited by IL-1β-IL-1RI to form the signaling-competent complex remains elusive. Here we present the crystal structure of IL-1β bound to IL-1 receptor type II (IL-1RII) and IL-1RAcP. IL-1β-IL-1RII generated a composite binding surface to recruit IL-1RAcP. Biochemical analysis demonstrated that IL-1β-IL-1RI and IL-1β-IL-1RII interacted similarly with IL-1RAcP. It also showed the importance of two loops of IL-1 receptor antagonist (IL-1Ra) in determining its antagonism. Our results provide a structural basis for assembly and activation of the IL-1 receptor and offer a general cytokine-receptor architecture that governs the IL-1 family of cytokines."xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1925"xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1925"xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/author | "Mei K."xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/author | "Mei K."xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/pages | "905-911"xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/pages | "905-911"xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/title | "Structural insights into the assembly and activation of IL-1beta with its receptors."xsd:string |
| http://purl.uniprot.org/citations/20802483 | http://purl.uniprot.org/core/title | "Structural insights into the assembly and activation of IL-1beta with its receptors."xsd:string |