| http://purl.uniprot.org/citations/20802485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20802485 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA double-strand break (DSB) repair occurs within chromatin and can be modulated by chromatin-modifying enzymes. Here we identify the related human histone deacetylases HDAC1 and HDAC2 as two participants in the DNA-damage response. We show that acetylation of histone H3 Lys56 (H3K56) was regulated by HDAC1 and HDAC2 and that HDAC1 and HDAC2 were rapidly recruited to DNA-damage sites to promote hypoacetylation of H3K56. Furthermore, HDAC1- and 2-depleted cells were hypersensitive to DNA-damaging agents and showed sustained DNA-damage signaling, phenotypes that reflect defective DSB repair, particularly by nonhomologous end-joining (NHEJ). Collectively, these results show that HDAC1 and HDAC2 function in the DNA-damage response by promoting DSB repair and thus provide important insights into the radio-sensitizing effects of HDAC inhibitors that are being developed as cancer therapies."xsd:string |
| http://purl.uniprot.org/citations/20802485 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.1899"xsd:string |
| http://purl.uniprot.org/citations/20802485 | http://purl.uniprot.org/core/author | "Jackson S.P."xsd:string |
| http://purl.uniprot.org/citations/20802485 | http://purl.uniprot.org/core/author | "Legube G."xsd:string |
| http://purl.uniprot.org/citations/20802485 | http://purl.uniprot.org/core/author | "Miller K.M."xsd:string |
| http://purl.uniprot.org/citations/20802485 | http://purl.uniprot.org/core/author | "Coates J."xsd:string |
| http://purl.uniprot.org/citations/20802485 | http://purl.uniprot.org/core/author | "Britton S."xsd:string |
| http://purl.uniprot.org/citations/20802485 | http://purl.uniprot.org/core/author | "Tjeertes J.V."xsd:string |
| http://purl.uniprot.org/citations/20802485 | http://purl.uniprot.org/core/author | "Polo S.E."xsd:string |
| http://purl.uniprot.org/citations/20802485 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20802485 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/20802485 | http://purl.uniprot.org/core/pages | "1144-1151"xsd:string |
| http://purl.uniprot.org/citations/20802485 | http://purl.uniprot.org/core/title | "Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining."xsd:string |
| http://purl.uniprot.org/citations/20802485 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/20802485 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20802485 |
| http://purl.uniprot.org/citations/20802485 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20802485 |
| http://purl.uniprot.org/uniprot/#_A0A7R6V290-mappedCitation-20802485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20802485 |
| http://purl.uniprot.org/uniprot/#_B4DSK9-mappedCitation-20802485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20802485 |
| http://purl.uniprot.org/uniprot/#_B7Z3S4-mappedCitation-20802485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20802485 |
| http://purl.uniprot.org/uniprot/#_B3KUJ5-mappedCitation-20802485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20802485 |
| http://purl.uniprot.org/uniprot/#_B4DRG0-mappedCitation-20802485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20802485 |
| http://purl.uniprot.org/uniprot/#_B5BU61-mappedCitation-20802485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20802485 |
| http://purl.uniprot.org/uniprot/#_B5MGH2-mappedCitation-20802485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20802485 |
| http://purl.uniprot.org/uniprot/#_Q13547-mappedCitation-20802485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20802485 |