| http://purl.uniprot.org/citations/20802527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20802527 | http://www.w3.org/2000/01/rdf-schema#comment | "Pancreatic adenocarcinoma upregulated factor (PAUF) is overproduced in certain types of cancer. However, little is known of the tumorigenic function of PAUF. In this study, we report the X-ray crystal structure of PAUF and reveal that PAUF is a mammalian lectin normally found in plant lectins. We also identify PAUF as an endogenous ligand of Toll-like receptor 2 (TLR2) and TLR4 by screening extracellular domain receptor pools. We further confirmed the specificity of the PAUF-TLR2 interaction. PAUF induces extracellular signal-regulated kinase (ERK) phosphorylation and activates the IKK-β-mediated TPL2/MEK/ERK signaling pathway through TLR2. In agreement with the result of TLR2-mediated ERK activation by PAUF, PAUF induces increased expression of the protumorigenic cytokines RANTES and MIF in THP-1 cells. However, PAUF does not fully activate Iκ-B-α signaling pathways in THP-1 cells, and fails to translocate the p65 subunit of the nuclear factor-κB (NF-κB) complex into the nucleus, resulting in no NF-κB activation. Surprisingly, we found that PAUF also associated with the CXC chemokine receptor (CXCR4)-TLR2 complex and inhibited CXCR4-dependent, TLR2-mediated NF-κB activation. Together, these findings suggest that the new cancer-associated ligand, PAUF, may activate TLR-mediated ERK signaling to produce the protumorigenic cytokines, but inhibits TLR-mediated NF-κB signaling, thereby facilitating tumor growth and escape from innate immune surveillance."xsd:string |
| http://purl.uniprot.org/citations/20802527 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2010.401"xsd:string |
| http://purl.uniprot.org/citations/20802527 | http://purl.uniprot.org/core/author | "Lee Y."xsd:string |
| http://purl.uniprot.org/citations/20802527 | http://purl.uniprot.org/core/author | "Kim K.H."xsd:string |
| http://purl.uniprot.org/citations/20802527 | http://purl.uniprot.org/core/author | "Myung K."xsd:string |
| http://purl.uniprot.org/citations/20802527 | http://purl.uniprot.org/core/author | "Koh S.S."xsd:string |
| http://purl.uniprot.org/citations/20802527 | http://purl.uniprot.org/core/author | "Park H.D."xsd:string |
| http://purl.uniprot.org/citations/20802527 | http://purl.uniprot.org/core/author | "Lim D.S."xsd:string |
| http://purl.uniprot.org/citations/20802527 | http://purl.uniprot.org/core/author | "Park Y.W."xsd:string |
| http://purl.uniprot.org/citations/20802527 | http://purl.uniprot.org/core/author | "Oh Y.K."xsd:string |
| http://purl.uniprot.org/citations/20802527 | http://purl.uniprot.org/core/author | "Jung J.G."xsd:string |
| http://purl.uniprot.org/citations/20802527 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20802527 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/20802527 | http://purl.uniprot.org/core/pages | "201-211"xsd:string |
| http://purl.uniprot.org/citations/20802527 | http://purl.uniprot.org/core/title | "Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation."xsd:string |
| http://purl.uniprot.org/citations/20802527 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/20802527 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20802527 |
| http://purl.uniprot.org/citations/20802527 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20802527 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DGN4-mappedCitation-20802527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20802527 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4S4-mappedCitation-20802527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20802527 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4L7-mappedCitation-20802527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20802527 |
| http://purl.uniprot.org/uniprot/#_A0A8D5XLR4-mappedCitation-20802527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20802527 |
| http://purl.uniprot.org/uniprot/#_A0A0U3FJG0-mappedCitation-20802527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20802527 |
| http://purl.uniprot.org/uniprot/#_A0A0U3GXA9-mappedCitation-20802527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20802527 |