| http://purl.uniprot.org/citations/20802536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20802536 | http://www.w3.org/2000/01/rdf-schema#comment | "Although Wnt-Frizzled (Fzd) signaling is critical in the pathophysiology of carcinomas, its role in human breast cancer has been difficult to establish. We show here that the adaptor protein Na(+)/H(+) exchange regulatory factor1 (NHERF1), a protein abundantly expressed in normal mammary epithelium, regulates Wnt signaling, maintaining low levels of β-catenin activation. NHERF1's effects are mediated by direct interactions between one of its PSD-95/drosophila discs large/ZO-1 (PDZ) domains and the C-terminus of a subset of Fzd receptors. Loss of NHERF1 in breast cancer cell lines enhances canonical Wnt signaling and Wnt-dependent cell proliferation. Furthermore, the mammary glands of NHERF1-knockout mice exhibit increased mammary duct density accompanied by increased proliferation and β-catenin activity. Finally, we demonstrate a negative correlation between NHERF1 expression and nuclear β-catenin in human breast carcinomas. Taken together, these results provide a novel insight into the regulation of Wnt signaling in normal and neoplastic breast tissues, and identify NHERF1 as an important regulator of the pathogenesis of breast tumors."xsd:string |
| http://purl.uniprot.org/citations/20802536 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2010.389"xsd:string |
| http://purl.uniprot.org/citations/20802536 | http://purl.uniprot.org/core/author | "Friedman P.A."xsd:string |
| http://purl.uniprot.org/citations/20802536 | http://purl.uniprot.org/core/author | "Romero G."xsd:string |
| http://purl.uniprot.org/citations/20802536 | http://purl.uniprot.org/core/author | "Wheeler D.S."xsd:string |
| http://purl.uniprot.org/citations/20802536 | http://purl.uniprot.org/core/author | "Barrick S.R."xsd:string |
| http://purl.uniprot.org/citations/20802536 | http://purl.uniprot.org/core/author | "Brufsky A.M."xsd:string |
| http://purl.uniprot.org/citations/20802536 | http://purl.uniprot.org/core/author | "Grubisha M.J."xsd:string |
| http://purl.uniprot.org/citations/20802536 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20802536 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/20802536 | http://purl.uniprot.org/core/pages | "32-42"xsd:string |
| http://purl.uniprot.org/citations/20802536 | http://purl.uniprot.org/core/title | "Direct interaction between NHERF1 and Frizzled regulates beta-catenin signaling."xsd:string |
| http://purl.uniprot.org/citations/20802536 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/20802536 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20802536 |
| http://purl.uniprot.org/citations/20802536 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20802536 |
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