| http://purl.uniprot.org/citations/20807769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20807769 | http://www.w3.org/2000/01/rdf-schema#comment | "The lipase activity of most phospholipases C (PLCs) is basally repressed by a highly degenerate and mostly disordered X/Y linker inserted within the catalytic domain. Release of this auto-inhibition is driven by electrostatic repulsion between the plasma membrane and the electronegative X/Y linker. In contrast, PLC-γ isozymes (PLC-γ1 and -γ2) are structurally distinct from other PLCs because multiple domains are present in their X/Y linker. Moreover, although many tyrosine kinases directly phosphorylate PLC-γ isozymes to enhance their lipase activity, the underlying molecular mechanism of this activation remains unclear. Here we define the mechanism for the unique regulation of PLC-γ isozymes by their X/Y linker. Specifically, we identify the C-terminal SH2 domain within the X/Y linker as the critical determinant for auto-inhibition. Tyrosine phosphorylation of the X/Y linker mediates high affinity intramolecular interaction with the C-terminal SH2 domain that is coupled to a large conformational rearrangement and release of auto-inhibition. Consequently, PLC-γ isozymes link phosphorylation to phospholipase activation by elaborating upon primordial regulatory mechanisms found in other PLCs."xsd:string |
| http://purl.uniprot.org/citations/20807769 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.166512"xsd:string |
| http://purl.uniprot.org/citations/20807769 | http://purl.uniprot.org/core/author | "Sondek J."xsd:string |
| http://purl.uniprot.org/citations/20807769 | http://purl.uniprot.org/core/author | "Harden T.K."xsd:string |
| http://purl.uniprot.org/citations/20807769 | http://purl.uniprot.org/core/author | "Hicks S.N."xsd:string |
| http://purl.uniprot.org/citations/20807769 | http://purl.uniprot.org/core/author | "Gresset A."xsd:string |
| http://purl.uniprot.org/citations/20807769 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20807769 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20807769 | http://purl.uniprot.org/core/pages | "35836-35847"xsd:string |
| http://purl.uniprot.org/citations/20807769 | http://purl.uniprot.org/core/title | "Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes."xsd:string |
| http://purl.uniprot.org/citations/20807769 | http://purl.uniprot.org/core/volume | "285"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A0C4DH25-mappedCitation-20807769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20807769 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DH73-mappedCitation-20807769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20807769 |
| http://purl.uniprot.org/uniprot/#_A0A075B6P5-mappedCitation-20807769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20807769 |
| http://purl.uniprot.org/uniprot/#_A0A075B6S6-mappedCitation-20807769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20807769 |
| http://purl.uniprot.org/uniprot/#_P0CF74-mappedCitation-20807769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20807769 |
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| http://purl.uniprot.org/uniprot/#_Q07889-mappedCitation-20807769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20807769 |
| http://purl.uniprot.org/uniprot/#_A2KUC3-mappedCitation-20807769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20807769 |
| http://purl.uniprot.org/uniprot/#_A2NJV5-mappedCitation-20807769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20807769 |
| http://purl.uniprot.org/uniprot/#_A2NXD2-mappedCitation-20807769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20807769 |