| http://purl.uniprot.org/citations/20810787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20810787 | http://www.w3.org/2000/01/rdf-schema#comment | "The Wnt-induced planar cell polarity (PCP) signaling pathway is essential for polarized cell migration and morphogenesis. Dishevelled (Dvl) and its binding protein Daam1 mediate RhoA activation in this pathway. WGEF, a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family, was shown to play a role in Wnt-induced RhoA activation in Xenopus embryos. However, it has remained unknown which member(s) of a Rho-GEF family are involved in Wnt/Dvl-induced RhoA activation in mammalian cells. Here we identified p114-RhoGEF and Lfc (also called GEF-H1) as the Rho-GEFs responsible for Wnt-3a-induced RhoA activation in N1E-115 mouse neuroblastoma cells. We screened for Rho-GEF-silencing short-hairpin RNAs (shRNAs) that are capable of suppressing Dvl-induced neurite retraction in N1E-115 cells and found that p114-RhoGEF and Lfc shRNAs, but not WGEF shRNA, suppressed Dvl- and Wnt-3a-induced neurite retraction. p114-RhoGEF and Lfc shRNAs also inhibited Dvl- and Wnt-3a-induced RhoA activation, and p114-RhoGEF and Lfc proteins were capable of binding to Dvl and Daam1. Additionally, the Dvl-binding domains of p114-RhoGEF and Lfc inhibited Dvl-induced neurite retraction. Our results suggest that p114-RhoGEF and Lfc are critically involved in Wnt-3a- and Dvl-induced RhoA activation and neurite retraction in N1E-115 cells."xsd:string |
| http://purl.uniprot.org/citations/20810787 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e10-02-0095"xsd:string |
| http://purl.uniprot.org/citations/20810787 | http://purl.uniprot.org/core/author | "Mizuno K."xsd:string |
| http://purl.uniprot.org/citations/20810787 | http://purl.uniprot.org/core/author | "Ohta Y."xsd:string |
| http://purl.uniprot.org/citations/20810787 | http://purl.uniprot.org/core/author | "Ohashi K."xsd:string |
| http://purl.uniprot.org/citations/20810787 | http://purl.uniprot.org/core/author | "Hirose K."xsd:string |
| http://purl.uniprot.org/citations/20810787 | http://purl.uniprot.org/core/author | "Kanno Y."xsd:string |
| http://purl.uniprot.org/citations/20810787 | http://purl.uniprot.org/core/author | "Tsuji T."xsd:string |
| http://purl.uniprot.org/citations/20810787 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20810787 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/20810787 | http://purl.uniprot.org/core/pages | "3590-3600"xsd:string |
| http://purl.uniprot.org/citations/20810787 | http://purl.uniprot.org/core/title | "Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells."xsd:string |
| http://purl.uniprot.org/citations/20810787 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/20810787 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20810787 |
| http://purl.uniprot.org/citations/20810787 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20810787 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWJ1-mappedCitation-20810787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20810787 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXF6-mappedCitation-20810787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20810787 |
| http://purl.uniprot.org/uniprot/#_A0A087WZG4-mappedCitation-20810787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20810787 |
| http://purl.uniprot.org/uniprot/#_D3YWI3-mappedCitation-20810787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20810787 |
| http://purl.uniprot.org/uniprot/#_A0A140LHF8-mappedCitation-20810787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20810787 |
| http://purl.uniprot.org/uniprot/#_A2A826-mappedCitation-20810787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20810787 |
| http://purl.uniprot.org/uniprot/#_A2A827-mappedCitation-20810787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20810787 |
| http://purl.uniprot.org/uniprot/#_A2A828-mappedCitation-20810787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20810787 |
| http://purl.uniprot.org/uniprot/#_A2A829-mappedCitation-20810787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20810787 |