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| http://purl.uniprot.org/citations/20814910 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitotic spindle length control requires coordination between microtubule (MT) dynamics and motor-generated forces. To investigate how MT plus-end polymerization contributes to spindle length in Drosophila embryos, we studied the dynamics of the MT plus-end depolymerase, kinesin-8, and the effects of kinesin-8 inhibition using mutants and antibody microinjection. As expected, kinesin-8 was found to contribute to anaphase A. Furthermore, kinesin-8 depletion caused: (i) excessive polymerization of interpolar (ip) MT plus ends, which "overgrow" to penetrate distal half spindles; (ii) an increase in the poleward ipMT sliding rate that is coupled to MT plus-end polymerization; (iii) premature spindle elongation during metaphase/anaphase A; and (iv) an increase in the anaphase B spindle elongation rate which correlates linearly with the MT sliding rate. This is best explained by a revised "ipMT sliding/minus-end depolymerization" model for spindle length control which incorporates a coupling between ipMT plus end dynamics and the outward ipMT sliding that drives poleward flux and spindle elongation."xsd:string |
| http://purl.uniprot.org/citations/20814910 | http://purl.org/dc/terms/identifier | "doi:10.1002/cm.20482"xsd:string |
| http://purl.uniprot.org/citations/20814910 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/20814910 | http://purl.uniprot.org/core/author | "Scholey J.M."xsd:string |
| http://purl.uniprot.org/citations/20814910 | http://purl.uniprot.org/core/author | "Brust-Mascher I."xsd:string |
| http://purl.uniprot.org/citations/20814910 | http://purl.uniprot.org/core/author | "Cheerambathur D."xsd:string |
| http://purl.uniprot.org/citations/20814910 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20814910 | http://purl.uniprot.org/core/name | "Cytoskeleton (Hoboken)"xsd:string |
| http://purl.uniprot.org/citations/20814910 | http://purl.uniprot.org/core/pages | "715-728"xsd:string |
| http://purl.uniprot.org/citations/20814910 | http://purl.uniprot.org/core/title | "Coupling between microtubule sliding, plus-end growth and spindle length revealed by kinesin-8 depletion."xsd:string |
| http://purl.uniprot.org/citations/20814910 | http://purl.uniprot.org/core/volume | "67"xsd:string |
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