| http://purl.uniprot.org/citations/20816090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20816090 | http://www.w3.org/2000/01/rdf-schema#comment | "The contribution of interleukin (IL)-6 signaling in obesity-induced inflammation remains controversial. To specifically define the role of hepatic IL-6 signaling in insulin action and resistance, we have generated mice with hepatocyte-specific IL-6 receptor (IL-6R) alpha deficiency (IL-6Ralpha(L-KO) mice). These animals showed no alterations in body weight and fat content but exhibited a reduction in insulin sensitivity and glucose tolerance. Impaired glucose metabolism originated from attenuated insulin-stimulated glucose transport in skeletal muscle and fat. Surprisingly, hepatic IL-6Ralpha-disruption caused an exaggerated inflammatory response during euglycemic hyperinsulinemic clamp analysis, as revealed by increased expression of IL-6, TNF-alpha, and IL-10, as well as enhanced activation of inflammatory signaling such as phosphorylation of IkappaBalpha. Neutralization of TNF-alpha or ablation of Kupffer cells restored glucose tolerance in IL-6Ralpha(L-KO) mice. Thus, our results reveal an unexpected role for hepatic IL-6 signaling to limit hepatic inflammation and to protect from local and systemic insulin resistance."xsd:string |
| http://purl.uniprot.org/citations/20816090 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2010.06.011"xsd:string |
| http://purl.uniprot.org/citations/20816090 | http://purl.uniprot.org/core/author | "Gruber S."xsd:string |
| http://purl.uniprot.org/citations/20816090 | http://purl.uniprot.org/core/author | "Li L.S."xsd:string |
| http://purl.uniprot.org/citations/20816090 | http://purl.uniprot.org/core/author | "Bruning J.C."xsd:string |
| http://purl.uniprot.org/citations/20816090 | http://purl.uniprot.org/core/author | "Libert C."xsd:string |
| http://purl.uniprot.org/citations/20816090 | http://purl.uniprot.org/core/author | "Wunderlich F.T."xsd:string |
| http://purl.uniprot.org/citations/20816090 | http://purl.uniprot.org/core/author | "Berggren P.O."xsd:string |
| http://purl.uniprot.org/citations/20816090 | http://purl.uniprot.org/core/author | "van Rooijen N."xsd:string |
| http://purl.uniprot.org/citations/20816090 | http://purl.uniprot.org/core/author | "Tovar S."xsd:string |
| http://purl.uniprot.org/citations/20816090 | http://purl.uniprot.org/core/author | "Juntti-Berggren L."xsd:string |
| http://purl.uniprot.org/citations/20816090 | http://purl.uniprot.org/core/author | "Strohle P."xsd:string |
| http://purl.uniprot.org/citations/20816090 | http://purl.uniprot.org/core/author | "Konner A.C."xsd:string |
| http://purl.uniprot.org/citations/20816090 | http://purl.uniprot.org/core/author | "Bronneke H.S."xsd:string |
| http://purl.uniprot.org/citations/20816090 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20816090 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/20816090 | http://purl.uniprot.org/core/pages | "237-249"xsd:string |
| http://purl.uniprot.org/citations/20816090 | http://purl.uniprot.org/core/title | "Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action."xsd:string |
| http://purl.uniprot.org/citations/20816090 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/20816090 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20816090 |
| http://purl.uniprot.org/citations/20816090 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20816090 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF1-mappedCitation-20816090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20816090 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF4-mappedCitation-20816090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20816090 |
| http://purl.uniprot.org/uniprot/#_Q0PMN1-mappedCitation-20816090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20816090 |