| http://purl.uniprot.org/citations/20817677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20817677 | http://www.w3.org/2000/01/rdf-schema#comment | "RNA-binding proteins (RBPs) play a major role in many post-transcriptional processes, including mRNA stability, alternative splicing and translation. PCBP4, also called MCG10, is an RBP belonging to the poly(C)-binding protein family and a target of p53 tumor suppressor. Ectopic expression of PCBP4 induces cell-cycle arrest in G₂ and apoptosis. To identify RNA targets regulated by PCBP4 and further decipher its function, we generated multiple cell lines in which PCBP4 is either inducibly over-expressed or knocked down. We found that PCBP4 expression decreases cyclin-dependent kinase inhibitor p21 induction in response to DNA damage. We also provided evidence that PCBP4 regulates p21 expression independently of p53. In addition, we showed that a deficiency in PCBP4 enhances p21 induction upon DNA damage. To validate PCBP4 regulation of p21, we made PCBP4-deficient mice and showed that p21 expression is markedly increased in PCBP4-deficient primary mouse embryo fibroblasts compared to that in wild-type counterparts. Finally, we uncovered that PCBP4 binds to the 3'-UTR of p21 transcript in vitro and in vivo to regulate p21 mRNA stability. Taken together, we revealed that PCBP4 regulates both basal and stress-induced p21 expression through binding p21 3'-UTR and modulating p21 mRNA stability."xsd:string |
| http://purl.uniprot.org/citations/20817677 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkq778"xsd:string |
| http://purl.uniprot.org/citations/20817677 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/20817677 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/20817677 | http://purl.uniprot.org/core/author | "Cho S.J."xsd:string |
| http://purl.uniprot.org/citations/20817677 | http://purl.uniprot.org/core/author | "Scoumanne A."xsd:string |
| http://purl.uniprot.org/citations/20817677 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20817677 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/20817677 | http://purl.uniprot.org/core/pages | "213-224"xsd:string |
| http://purl.uniprot.org/citations/20817677 | http://purl.uniprot.org/core/title | "The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability."xsd:string |
| http://purl.uniprot.org/citations/20817677 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/20817677 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20817677 |
| http://purl.uniprot.org/citations/20817677 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20817677 |
| http://purl.uniprot.org/uniprot/P57724#attribution-DCFE4DBB394530F92AA43E2847570E73 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20817677 |
| http://purl.uniprot.org/uniprot/P57723#attribution-D352736A2372A5CF7D7E45E54F1E82FD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20817677 |
| http://purl.uniprot.org/uniprot/#_A0A087WQ06-mappedCitation-20817677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20817677 |
| http://purl.uniprot.org/uniprot/#_A0A087WP16-mappedCitation-20817677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20817677 |
| http://purl.uniprot.org/uniprot/#_A0A087WPG7-mappedCitation-20817677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20817677 |
| http://purl.uniprot.org/uniprot/#_A0A087WSI1-mappedCitation-20817677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20817677 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SSM1-mappedCitation-20817677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20817677 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SUS5-mappedCitation-20817677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20817677 |
| http://purl.uniprot.org/uniprot/#_A0A087WR61-mappedCitation-20817677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20817677 |
| http://purl.uniprot.org/uniprot/#_A0A087WRH3-mappedCitation-20817677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20817677 |
| http://purl.uniprot.org/uniprot/#_A0A087WRJ6-mappedCitation-20817677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20817677 |