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http://purl.uniprot.org/citations/20818075http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20818075http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the association of tyrosine hydroxylase (TH) C-824T polymorphism with essential hypertension (EH) susceptibility in Hunan Han population by a case-control study.

Methods

A case-control study was performed on 368 EH patients and 353 healthy controls of Han nationality recruited in Hunan province. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)was used to genotype the C-824T polymorphism.

Results

(1) Genotype frequencies for TH-824CC and -824CT+-824TT genotypes were 89.9% and 10.1%, respectively for EH patients and 88.7% and 11.3%, respectively for the controls. No significant difference in the genotype distribution of C-824T polymorphism between the patients and controls was observed (P=0.579). Allele frequencies of TH C-824T also showed no significant difference between the patients and controls (P=0.515). (2) When adjusted by EH risk factors, results of unconditional logistic regression analysis showed that there was no association between TH C-824T polymorphism and EH susceptibility (P=0.264). (3) When stratified by gender, no significant difference in the genotype distribution of TH C-824T polymorphism was observed between the patients and controls in either male or female subjects (P=0.841 and P=0.288). (4) Diastolic blood pressure (DBP) in individuals with -824 CT+TT genotype was significantly higher than that in individuals with -824 CC genotype in the controls (P=0.015). (5) When stratified by gender, significant difference in DBP between TH C-824T CT+TT genotype and CC genotype was observed in the male (P= 0.018) but not in the female (P=0.083) controls.

Conclusion

There is no association between TH gene C-824T polymorphism and EH susceptibility in Hunan Han population. The TH gene C-824T polymorphism is possibly associated with increased DBP in the males in Hunan Han population."xsd:string
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http://purl.uniprot.org/citations/20818075http://purl.uniprot.org/core/author"Chen A."xsd:string
http://purl.uniprot.org/citations/20818075http://purl.uniprot.org/core/author"Chen J."xsd:string
http://purl.uniprot.org/citations/20818075http://purl.uniprot.org/core/author"Chen L."xsd:string
http://purl.uniprot.org/citations/20818075http://purl.uniprot.org/core/author"Bai Y."xsd:string
http://purl.uniprot.org/citations/20818075http://purl.uniprot.org/core/author"Chen X."xsd:string
http://purl.uniprot.org/citations/20818075http://purl.uniprot.org/core/author"Guo Y."xsd:string
http://purl.uniprot.org/citations/20818075http://purl.uniprot.org/core/author"Shi R."xsd:string
http://purl.uniprot.org/citations/20818075http://purl.uniprot.org/core/author"Zhang G."xsd:string
http://purl.uniprot.org/citations/20818075http://purl.uniprot.org/core/author"Yang T."xsd:string
http://purl.uniprot.org/citations/20818075http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20818075http://purl.uniprot.org/core/name"Zhong Nan Da Xue Xue Bao Yi Xue Ban"xsd:string
http://purl.uniprot.org/citations/20818075http://purl.uniprot.org/core/pages"826-832"xsd:string
http://purl.uniprot.org/citations/20818075http://purl.uniprot.org/core/title"[Genetic polymorphism in tyrosine hydroxylase gene and essential hypertension in Hunan Han population]."xsd:string
http://purl.uniprot.org/citations/20818075http://purl.uniprot.org/core/volume"35"xsd:string
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