| http://purl.uniprot.org/citations/20819778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20819778 | http://www.w3.org/2000/01/rdf-schema#comment | "Second primary tumor (SPT) and/or recurrence negatively impact the prognosis of patients with curatively treated early-stage head and neck cancer. MicroRNAs (miRNAs) play important roles in cancer development. We explored whether the variations of miRNA-related pathway were associated with the risk of SPT/recurrence in patients with early-stage head and neck cancer. This study includes 150 early-stage head and neck cancer patients with SPT/recurrence and 300 patients without SPT/recurrence. Two hundred and thirty-five tagging and potentially functional single-nucleotide polymorphisms (SNPs) were genotyped from eight miRNA biogenesis pathway genes and 135 miRNA-targeted genes. Eighteen miRNA-related SNPs were significantly associated with the risk of SPT/recurrence. The most significant SNP was rs3747238, a miRNA-binding site SNP in SMC1B. The variant homozygous genotype of this SNP was associated with a 1.74-fold increased risk [95% confidence interval (CI) 1.19-2.54; P = 0.004]. Cumulative effect analysis showed joint effects for the number of unfavorable genotype in patients. Survival tree analysis further identified the high-order gene-gene interactions and categorized the study subjects into low-, medium- and high-risk groups. Patients in the high-risk group had a 4.84-fold increased risk (95% CI: 3.11-7.51; P = 2.45 × 10(-12)) and a shorter event-free median survival time of 37.9 months (log rank P = 2.28 × 10(-13)). Our results suggested that miRNA-related genetic polymorphisms may be used individually and jointly to predict the risk of SPT/recurrence of early-stage head and neck cancer patients."xsd:string |
| http://purl.uniprot.org/citations/20819778 | http://purl.org/dc/terms/identifier | "doi:10.1093/carcin/bgq177"xsd:string |
| http://purl.uniprot.org/citations/20819778 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/20819778 | http://purl.uniprot.org/core/author | "Lee J.J."xsd:string |
| http://purl.uniprot.org/citations/20819778 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/20819778 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/20819778 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/20819778 | http://purl.uniprot.org/core/author | "Spitz M.R."xsd:string |
| http://purl.uniprot.org/citations/20819778 | http://purl.uniprot.org/core/author | "Lotan R."xsd:string |
| http://purl.uniprot.org/citations/20819778 | http://purl.uniprot.org/core/author | "Khuri F.R."xsd:string |
| http://purl.uniprot.org/citations/20819778 | http://purl.uniprot.org/core/author | "Hong W.K."xsd:string |
| http://purl.uniprot.org/citations/20819778 | http://purl.uniprot.org/core/author | "Lippman S.M."xsd:string |
| http://purl.uniprot.org/citations/20819778 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20819778 | http://purl.uniprot.org/core/name | "Carcinogenesis"xsd:string |
| http://purl.uniprot.org/citations/20819778 | http://purl.uniprot.org/core/pages | "2118-2123"xsd:string |
| http://purl.uniprot.org/citations/20819778 | http://purl.uniprot.org/core/title | "MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer."xsd:string |
| http://purl.uniprot.org/citations/20819778 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/20819778 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20819778 |
| http://purl.uniprot.org/citations/20819778 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20819778 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DH20-mappedCitation-20819778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20819778 |
| http://purl.uniprot.org/uniprot/#_A0A087WTR9-mappedCitation-20819778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20819778 |
| http://purl.uniprot.org/uniprot/#_A0A087WUE3-mappedCitation-20819778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20819778 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MRL7-mappedCitation-20819778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20819778 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1S3-mappedCitation-20819778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20819778 |