| http://purl.uniprot.org/citations/20825495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20825495 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclin-dependent protein kinases (CDKs) are required for various cell cycle events both in mitosis and in meiosis. During the meiotic prophase of Saccharomyces cerevisiae, only one CDK, Cdc28, which forms a complex with B-type cyclins, Clb5 or Clb6, promotes not only the onset of premeiotic DNA replication but also the formation of meiotic double-strand breaks (DSBs). In this study, we showed that Cdc28 exhibits punctate staining on chromosomes during meiotic prophase I. Chromosomal localization of Cdc28, dependent on Clb5 and/or Clb6, is frequently observed in zygotene and pachytene, when formation of the synaptonemal complex (SC) occurs. Interestingly, the CDK localization is independent of DSB formation, but rather dependent on meiosis-specific chromosome components such as Red1, Hop1 and a cohesin subunit Rec8. Compromised CDK activity in meiotic prophase leads to defective SC formation without affecting DSB formation. These results suggest that CDK-dependent phosphorylation regulates meiotic chromosome morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/20825495 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2010.01440.x"xsd:string |
| http://purl.uniprot.org/citations/20825495 | http://purl.uniprot.org/core/author | "Mori S."xsd:string |
| http://purl.uniprot.org/citations/20825495 | http://purl.uniprot.org/core/author | "Zhu Z."xsd:string |
| http://purl.uniprot.org/citations/20825495 | http://purl.uniprot.org/core/author | "Matsuzaki K."xsd:string |
| http://purl.uniprot.org/citations/20825495 | http://purl.uniprot.org/core/author | "Shinohara M."xsd:string |
| http://purl.uniprot.org/citations/20825495 | http://purl.uniprot.org/core/author | "Shinohara A."xsd:string |
| http://purl.uniprot.org/citations/20825495 | http://purl.uniprot.org/core/author | "Oshiumi H."xsd:string |
| http://purl.uniprot.org/citations/20825495 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20825495 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/20825495 | http://purl.uniprot.org/core/pages | "1036-1050"xsd:string |
| http://purl.uniprot.org/citations/20825495 | http://purl.uniprot.org/core/title | "Cyclin-dependent kinase promotes formation of the synaptonemal complex in yeast meiosis."xsd:string |
| http://purl.uniprot.org/citations/20825495 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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