| http://purl.uniprot.org/citations/20826341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20826341 | http://www.w3.org/2000/01/rdf-schema#comment | "BLM, the protein product of the gene mutated in Bloom syndrome, is one of five human RecQ helicases. It functions to separate double Holliday junction DNA without genetic exchange as a component of the "dissolvasome," which also includes topoisomerase IIIα and the RMI (RecQ-mediated genome instability) subcomplex (RMI1 and RMI2). We describe the crystal structure of the RMI core complex, comprising RMI2 and the C-terminal OB domain of RMI1. The overall RMI core structure strongly resembles two-thirds of the trimerization core of the eukaryotic single-stranded DNA-binding protein, Replication Protein A. Immunoprecipitation experiments with RMI2 variants confirm key interactions that stabilize the RMI core interface. Disruption of this interface leads to a dramatic increase in cellular sister chromatid exchange events similar to that seen in BLM-deficient cells. The RMI core interface is therefore crucial for BLM dissolvasome assembly and may have additional cellular roles as a docking hub for other proteins."xsd:string |
| http://purl.uniprot.org/citations/20826341 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2010.06.009"xsd:string |
| http://purl.uniprot.org/citations/20826341 | http://purl.uniprot.org/core/author | "Xu D."xsd:string |
| http://purl.uniprot.org/citations/20826341 | http://purl.uniprot.org/core/author | "Xue Y."xsd:string |
| http://purl.uniprot.org/citations/20826341 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/20826341 | http://purl.uniprot.org/core/author | "Satyshur K.A."xsd:string |
| http://purl.uniprot.org/citations/20826341 | http://purl.uniprot.org/core/author | "Keck J.L."xsd:string |
| http://purl.uniprot.org/citations/20826341 | http://purl.uniprot.org/core/author | "Hoadley K.A."xsd:string |
| http://purl.uniprot.org/citations/20826341 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20826341 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/20826341 | http://purl.uniprot.org/core/pages | "1149-1158"xsd:string |
| http://purl.uniprot.org/citations/20826341 | http://purl.uniprot.org/core/title | "Structure and cellular roles of the RMI core complex from the bloom syndrome dissolvasome."xsd:string |
| http://purl.uniprot.org/citations/20826341 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/20826341 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20826341 |
| http://purl.uniprot.org/citations/20826341 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20826341 |
| http://purl.uniprot.org/uniprot/#_Q96E14-mappedCitation-20826341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20826341 |
| http://purl.uniprot.org/uniprot/#_Q9H9A7-mappedCitation-20826341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20826341 |
| http://purl.uniprot.org/uniprot/Q96E14 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20826341 |
| http://purl.uniprot.org/uniprot/Q9H9A7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20826341 |