| http://purl.uniprot.org/citations/20826778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20826778 | http://www.w3.org/2000/01/rdf-schema#comment | "E2-25K/Hip2 is an unusual ubiquitin-conjugating enzyme that interacts with the frameshift mutant of ubiquitin B (UBB(+1)) and has been identified as a crucial factor regulating amyloid-β neurotoxicity. To study the structural basis of the neurotoxicity mediated by the E2-25K-UBB(+1) interaction, we determined the three-dimensional structures of UBB(+1), E2-25K and the E2-25K/ubiquitin, and E2-25K/UBB(+1) complex. The structures revealed that ubiquitin or UBB(+1) is bound to E2-25K via the enzyme MGF motif and residues in α9 of the enzyme. Polyubiquitylation assays together with analyses of various E2-25K mutants showed that disrupting UBB(+1) binding markedly diminishes synthesis of neurotoxic UBB(+1)-anchored polyubiquitin. These results suggest that the interaction between E2-25K and UBB(+1) is critical for the synthesis and accumulation of UBB(+1)-anchored polyubiquitin, which results in proteasomal inhibition and neuronal cell death."xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.145219"xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/author | "Arrowsmith C.H."xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/author | "Ko S."xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/author | "Sheng Y."xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/author | "Lee W."xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/author | "Song S.M."xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/author | "Eom S.H."xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/author | "Kang G.B."xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/author | "Dhe-Paganon S."xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/author | "Cheong C."xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/author | "Jeon Y.H."xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/author | "Yoo Y.J."xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/author | "Lee J.G."xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/author | "Shin D.Y."xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/author | "Jung Y.K."xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/author | "Avvakumov G.V."xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/author | "Yun J.H."xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/pages | "36070-36080"xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/title | "Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity."xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20826778 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20826778 |