http://purl.uniprot.org/citations/20829061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/20829061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/20829061 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of this study is to investigate if macrophage-colony stimulating factor (M-CSF) or interleukin-34 (IL-34) induces cytokines or chemokines using human whole blood (HWB) and if an M-CSF- or IL-34-induced cytokine or chemokine production from HWB is inhibited by soluble M-CSF receptor or c-FMS kinase inhibitors. Among eight cytokines or growth factors tested, only IL-6 level was increased by up to 6-fold by M-CSF or IL-34 in HWB. In contrast, chemokine levels (IP-10/CXCL10, IL-8/CXCL8, and MCP-1/CCL2) were dramatically increased by M-CSF or IL-34 in HWB while exhibiting a large variation among donors. Variability of the MCP-1 signal induced by M-CSF or IL-34 was relatively less among donors compared to the IP-10 and IL-8 signals. The elevation of these chemokine levels was significantly decreased by soluble M-CSF receptor, indicating the elevation of these chemokines was mediated by M-CSF or IL-34. Furthermore, GW2580, a c-FMS kinase inhibitor, inhibited the induction of MCP-1 by M-CSF or IL-34 in a concentration dependent manner. These indicate MCP-1 is the most appropriate chemokine target for a chemokine release assay to evaluate the potency of c-FMS kinase inhibitors and MCP-1 release assay using HWB would be useful, relevant tool for translational pharmacology of c-FMS kinase inhibitors."xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cyto.2010.08.005"xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cyto.2010.08.005"xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/author | "Eda H."xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/author | "Eda H."xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/author | "Beidler D.R."xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/author | "Beidler D.R."xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/author | "Monahan J.B."xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/author | "Monahan J.B."xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/author | "Keith R.H."xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/author | "Keith R.H."xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/author | "Michener M."xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/author | "Michener M."xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/name | "Cytokine"xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/name | "Cytokine"xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/pages | "215-220"xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/pages | "215-220"xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/title | "Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood."xsd:string |
http://purl.uniprot.org/citations/20829061 | http://purl.uniprot.org/core/title | "Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood."xsd:string |