| http://purl.uniprot.org/citations/20832498 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20832498 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuregulin-1 (Nrg1) provides a key axonal signal that regulates Schwann cell proliferation, migration and myelination through binding to ErbB2/3 receptors. The analysis of a number of genetic models has unmasked fundamental mechanisms underlying the specificity of the Nrg1/ErbB signaling axis. Differential expression of Nrg1 isoforms, Nrg1 processing, and ErbB receptor localization and trafficking represent important regulatory themes in the control of Nrg1/ErbB function. Nrg1 binding to ErbB2/3 receptors results in the activation of intracellular signal transduction pathways that initiate changes in Schwann cell behavior. Here, we review data that has defined the role of key Nrg1/ErbB signaling components like Shp2, ERK1/2, FAK, Rac1/Cdc42 and calcineurin in development of the Schwann cell lineage in vivo. Many of these regulators receive converging signals from other cues that are provided by Notch, integrin or G-protein coupled receptors. Signaling by multiple extracellular factors may act as key modifiers and allow Schwann cells at different developmental stages to respond in distinct manners to the Nrg1/ErbB signal."xsd:string |
| http://purl.uniprot.org/citations/20832498 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.semcdb.2010.08.008"xsd:string |
| http://purl.uniprot.org/citations/20832498 | http://purl.uniprot.org/core/author | "Birchmeier C."xsd:string |
| http://purl.uniprot.org/citations/20832498 | http://purl.uniprot.org/core/author | "Newbern J."xsd:string |
| http://purl.uniprot.org/citations/20832498 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20832498 | http://purl.uniprot.org/core/name | "Semin Cell Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/20832498 | http://purl.uniprot.org/core/pages | "922-928"xsd:string |
| http://purl.uniprot.org/citations/20832498 | http://purl.uniprot.org/core/title | "Nrg1/ErbB signaling networks in Schwann cell development and myelination."xsd:string |
| http://purl.uniprot.org/citations/20832498 | http://purl.uniprot.org/core/volume | "21"xsd:string |
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| http://purl.uniprot.org/uniprot/#_Q86SQ4-mappedCitation-20832498 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20832498 |
| http://purl.uniprot.org/uniprot/#_P51532-mappedCitation-20832498 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20832498 |
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| http://purl.uniprot.org/uniprot/#_Q92769-mappedCitation-20832498 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20832498 |
| http://purl.uniprot.org/uniprot/Q92769 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20832498 |
| http://purl.uniprot.org/uniprot/Q03052 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20832498 |
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| http://purl.uniprot.org/uniprot/P56693 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20832498 |