| http://purl.uniprot.org/citations/20833111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20833111 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of this study was to investigate the association between carbamazepine (CBZ)-induced cutaneous adverse drug reactions (cADRs) and the HLA-B*1502 allele among patients from central China. Eight patients with Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN), 28 with mild maculopapular eruptions (MPEs), 50 CBZ-tolerant controls, and 71 healthy volunteers were recruited. HLA genotyping was performed using the polymerase chain reaction sequence-based typing (SBT) method. As a result, the HLA-B*1502 allele was observed at the following rates: (1) 100% (8/8) among those with CBZ-induced SJS/TEN, (2) 10.7% (3/28) among those with CBZ-induced MPEs; (3) 8.0% (4/50) among CBZ-tolerant controls; (4) 8.5% (6/71) among healthy volunteers. The eight patients with SJS/TEN positive for the HLA-B*1502 allele had an odds ratio (OR) of 184 compared with CBZ-tolerant controls. There was no significant difference in frequency between patients with MPEs and CBZ-tolerant controls (P>0.05). Thus, CBZ-induced SJS/TEN, but not MPEs, is strongly associated with HLA-B*1502. Testing for HLA-B*1502 should be recommended for patients from central China prior to initial CBZ treatment."xsd:string |
| http://purl.uniprot.org/citations/20833111 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yebeh.2010.08.007"xsd:string |
| http://purl.uniprot.org/citations/20833111 | http://purl.uniprot.org/core/author | "Jiang X."xsd:string |
| http://purl.uniprot.org/citations/20833111 | http://purl.uniprot.org/core/author | "Zhou D."xsd:string |
| http://purl.uniprot.org/citations/20833111 | http://purl.uniprot.org/core/author | "Yan B."xsd:string |
| http://purl.uniprot.org/citations/20833111 | http://purl.uniprot.org/core/author | "Kwan P."xsd:string |
| http://purl.uniprot.org/citations/20833111 | http://purl.uniprot.org/core/author | "Hu F.Y."xsd:string |
| http://purl.uniprot.org/citations/20833111 | http://purl.uniprot.org/core/author | "Wu X.T."xsd:string |
| http://purl.uniprot.org/citations/20833111 | http://purl.uniprot.org/core/author | "Stefan H."xsd:string |
| http://purl.uniprot.org/citations/20833111 | http://purl.uniprot.org/core/author | "An D.M."xsd:string |
| http://purl.uniprot.org/citations/20833111 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20833111 | http://purl.uniprot.org/core/name | "Epilepsy Behav"xsd:string |
| http://purl.uniprot.org/citations/20833111 | http://purl.uniprot.org/core/pages | "405-408"xsd:string |
| http://purl.uniprot.org/citations/20833111 | http://purl.uniprot.org/core/title | "Association between carbamazepine-induced cutaneous adverse drug reactions and the HLA-B*1502 allele among patients in central China."xsd:string |
| http://purl.uniprot.org/citations/20833111 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/20833111 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20833111 |
| http://purl.uniprot.org/citations/20833111 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20833111 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-20833111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20833111 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-20833111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20833111 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-20833111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20833111 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-20833111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20833111 |
| http://purl.uniprot.org/uniprot/#_A0A068B107-mappedCitation-20833111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20833111 |
| http://purl.uniprot.org/uniprot/#_A0A068B112-mappedCitation-20833111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20833111 |
| http://purl.uniprot.org/uniprot/#_A0A068B116-mappedCitation-20833111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20833111 |