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| http://purl.uniprot.org/citations/20833144 | http://www.w3.org/2000/01/rdf-schema#comment | "The hypothesis, that structural deterioration of cytochrome c oxidase (CcO) is a causal factor in the age-related decline in mitochondrial respiratory activity and an increase in H₂O₂ generation, was tested in Drosophila melanogaster. CcO activity and the levels of seven different nuclear DNA-encoded CcO subunits were determined at three different stages of adult life, namely, young-, middle-, and old-age. CcO activity declined progressively with age by 33%. Western blot analysis, using antibodies specific to Drosophila CcO subunits IV, Va, Vb, VIb, VIc, VIIc, and VIII, indicated that the abundance these polypeptides decreased, ranging from 11% to 40%, during aging. These and previous results suggest that CcO is a specific intra-mitochondrial site of age-related deterioration, which may have a broad impact on mitochondrial physiology."xsd:string |
| http://purl.uniprot.org/citations/20833144 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2010.09.009"xsd:string |
| http://purl.uniprot.org/citations/20833144 | http://purl.uniprot.org/core/author | "Rebrin I."xsd:string |
| http://purl.uniprot.org/citations/20833144 | http://purl.uniprot.org/core/author | "Orr W.C."xsd:string |
| http://purl.uniprot.org/citations/20833144 | http://purl.uniprot.org/core/author | "Sohal R.S."xsd:string |
| http://purl.uniprot.org/citations/20833144 | http://purl.uniprot.org/core/author | "Ren J.C."xsd:string |
| http://purl.uniprot.org/citations/20833144 | http://purl.uniprot.org/core/author | "Klichko V."xsd:string |
| http://purl.uniprot.org/citations/20833144 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20833144 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/20833144 | http://purl.uniprot.org/core/pages | "64-68"xsd:string |
| http://purl.uniprot.org/citations/20833144 | http://purl.uniprot.org/core/title | "Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/20833144 | http://purl.uniprot.org/core/volume | "401"xsd:string |
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