| http://purl.uniprot.org/citations/20835248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20835248 | http://www.w3.org/2000/01/rdf-schema#comment | "We propose that a C-type lectin receptor, SIGNR-1 (also called Cd209b), helps to condition dendritic cells (DCs) in the gastrointestinal lamina propria (LPDCs) for the induction of oral tolerance in a model of food-induced anaphylaxis. Oral delivery of BSA bearing 51 molecules of mannoside (Man(51)-BSA) substantially reduced the BSA-induced anaphylactic response. Man(51)-BSA selectively targeted LPDCs that expressed SIGNR1 and induced the expression of interleukin-10 (IL-10), but not IL-6 or IL-12 p70. We found the same effects in IL-10-GFP knock-in (tiger) mice treated with Man(51)-BSA. The Man(51)-BSA-SIGNR1 axis in LPDCs, both in vitro and in vivo, promoted the generation of CD4(+) type 1 regulatory T (Tr1)-like cells that expressed IL-10 and interferon-γ (IFN-γ), in a SIGNR-1- and IL-10-dependent manner, but not of CD4(+)CD25(+)Foxp3(+) regulatory T cells. The Tr1-like cells could transfer tolerance. These results suggest that sugar-modified antigens might be used to induce oral tolerance by targeting SIGNR1 and LPDCs."xsd:string |
| http://purl.uniprot.org/citations/20835248 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.2201"xsd:string |
| http://purl.uniprot.org/citations/20835248 | http://purl.uniprot.org/core/author | "Yang K."xsd:string |
| http://purl.uniprot.org/citations/20835248 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/20835248 | http://purl.uniprot.org/core/author | "Lee Y.C."xsd:string |
| http://purl.uniprot.org/citations/20835248 | http://purl.uniprot.org/core/author | "Kawasaki H."xsd:string |
| http://purl.uniprot.org/citations/20835248 | http://purl.uniprot.org/core/author | "Fu J."xsd:string |
| http://purl.uniprot.org/citations/20835248 | http://purl.uniprot.org/core/author | "Plunkett B."xsd:string |
| http://purl.uniprot.org/citations/20835248 | http://purl.uniprot.org/core/author | "Yao X."xsd:string |
| http://purl.uniprot.org/citations/20835248 | http://purl.uniprot.org/core/author | "Lee R.T."xsd:string |
| http://purl.uniprot.org/citations/20835248 | http://purl.uniprot.org/core/author | "Hsu S.C."xsd:string |
| http://purl.uniprot.org/citations/20835248 | http://purl.uniprot.org/core/author | "Huang S.K."xsd:string |
| http://purl.uniprot.org/citations/20835248 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20835248 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/20835248 | http://purl.uniprot.org/core/pages | "1128-1133"xsd:string |
| http://purl.uniprot.org/citations/20835248 | http://purl.uniprot.org/core/title | "Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1."xsd:string |
| http://purl.uniprot.org/citations/20835248 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/20835248 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20835248 |
| http://purl.uniprot.org/citations/20835248 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20835248 |
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| http://purl.uniprot.org/uniprot/#_P18893-mappedCitation-20835248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20835248 |
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| http://purl.uniprot.org/uniprot/#_Q8CJ85-mappedCitation-20835248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20835248 |