| http://purl.uniprot.org/citations/20835250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20835250 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendritic spines undergo actin-based growth and shrinkage during synaptic plasticity, in which the actin depolymerizing factor (ADF)/cofilin family of actin-associated proteins are important. Elevated ADF/cofilin activities often lead to reduced spine size and immature spine morphology but can also enhance synaptic potentiation in some cases. Thus, ADF/cofilin may have distinct effects on postsynaptic structure and function. We found that ADF/cofilin-mediated actin dynamics regulated AMPA receptor (AMPAR) trafficking during synaptic potentiation, which was distinct from actin's structural role in spine morphology. Specifically, elevated ADF/cofilin activity markedly enhanced surface addition of AMPARs after chemically induced long-term potentiation (LTP), whereas inhibition of ADF/cofilin abolished AMPAR addition. We found that chemically induced LTP elicited a temporal sequence of ADF/cofilin dephosphorylation and phosphorylation that underlies AMPAR trafficking and spine enlargement. These findings suggest that temporally regulated ADF/cofilin activities function in postsynaptic modifications of receptor number and spine size during synaptic plasticity."xsd:string |
| http://purl.uniprot.org/citations/20835250 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.2634"xsd:string |
| http://purl.uniprot.org/citations/20835250 | http://purl.uniprot.org/core/author | "Bamburg J.R."xsd:string |
| http://purl.uniprot.org/citations/20835250 | http://purl.uniprot.org/core/author | "Chen G."xsd:string |
| http://purl.uniprot.org/citations/20835250 | http://purl.uniprot.org/core/author | "Gu J."xsd:string |
| http://purl.uniprot.org/citations/20835250 | http://purl.uniprot.org/core/author | "Fan Y."xsd:string |
| http://purl.uniprot.org/citations/20835250 | http://purl.uniprot.org/core/author | "Sun C."xsd:string |
| http://purl.uniprot.org/citations/20835250 | http://purl.uniprot.org/core/author | "Tang X."xsd:string |
| http://purl.uniprot.org/citations/20835250 | http://purl.uniprot.org/core/author | "Yu K."xsd:string |
| http://purl.uniprot.org/citations/20835250 | http://purl.uniprot.org/core/author | "Hartzell H.C."xsd:string |
| http://purl.uniprot.org/citations/20835250 | http://purl.uniprot.org/core/author | "Lee C.W."xsd:string |
| http://purl.uniprot.org/citations/20835250 | http://purl.uniprot.org/core/author | "Zheng J.Q."xsd:string |
| http://purl.uniprot.org/citations/20835250 | http://purl.uniprot.org/core/author | "Komlos D."xsd:string |
| http://purl.uniprot.org/citations/20835250 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20835250 | http://purl.uniprot.org/core/name | "Nat Neurosci"xsd:string |
| http://purl.uniprot.org/citations/20835250 | http://purl.uniprot.org/core/pages | "1208-1215"xsd:string |
| http://purl.uniprot.org/citations/20835250 | http://purl.uniprot.org/core/title | "ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity."xsd:string |
| http://purl.uniprot.org/citations/20835250 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/20835250 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20835250 |
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| http://purl.uniprot.org/uniprot/P60981 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20835250 |