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http://purl.uniprot.org/citations/20835340http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Background

The Reg gene has been reported to be expressed in regenerating islets and Reg1 protein to be up-regulated at an early stage of diabetes in mice. As human Reg1α is homologous with murine Reg1, we investigated whether common variants in Reg1α are associated with type 2 diabetes in the Korean population.

Methods

We sequenced the Reg1α gene to identify common polymorphisms using 24 Korean DNA samples. Of 11 polymorphisms found, five common ones (g.-385T>C [rs10165462], g.-36T>G [rs25689789], g.209G>T [rs2070707], g.1385C>G [novel], and g.2199G>A [novel]) were genotyped in 752 type 2 diabetic patients and 642 non-diabetic subjects.

Results

No polymorphism was associated with the risk of type 2 diabetes. However, g.-385C and g.2199A lowered the risk of early-onset type 2 diabetes, defined as a diagnosis in subjects whose age at diagnosis was 25 years or more but less than 40 years (odds ratio [OR], 0.721 [0.535 to 0.971] and 0.731 [0.546 to 0.977] for g.-385C and g.2199A, respectively) and g.1385G increased the risk of early-onset diabetes (OR, 1.398 [1.055 to 1.854]). Although adjusting for errors in multiple hypotheses-testing showed no statistically significant association between the three individual polymorphisms and early-onset diabetes, the haplotype H1, composed of g.-385C, g.1385C, and g.2199A, was associated with a reduced risk of early-onset diabetes (OR, 0.590 [0.396 to 0.877], P = 0.009).

Conclusion

Polymorphisms in the Reg1α were not found to be associated with overall susceptibility to type 2 diabetes, though some showed modest associations with early-onset type 2 diabetes in the Korean population."xsd:string
http://purl.uniprot.org/citations/20835340http://purl.org/dc/terms/identifier"doi:10.4093/kdj.2010.34.4.229"xsd:string
http://purl.uniprot.org/citations/20835340http://purl.uniprot.org/core/author"Lee H.K."xsd:string
http://purl.uniprot.org/citations/20835340http://purl.uniprot.org/core/author"Park S.G."xsd:string
http://purl.uniprot.org/citations/20835340http://purl.uniprot.org/core/author"Park K.S."xsd:string
http://purl.uniprot.org/citations/20835340http://purl.uniprot.org/core/author"Lee J.Y."xsd:string
http://purl.uniprot.org/citations/20835340http://purl.uniprot.org/core/author"Koo B.K."xsd:string
http://purl.uniprot.org/citations/20835340http://purl.uniprot.org/core/author"Oh B."xsd:string
http://purl.uniprot.org/citations/20835340http://purl.uniprot.org/core/author"Cho Y.M."xsd:string
http://purl.uniprot.org/citations/20835340http://purl.uniprot.org/core/author"Park B.L."xsd:string
http://purl.uniprot.org/citations/20835340http://purl.uniprot.org/core/author"Shin H.D."xsd:string
http://purl.uniprot.org/citations/20835340http://purl.uniprot.org/core/author"Ko K.S."xsd:string
http://purl.uniprot.org/citations/20835340http://purl.uniprot.org/core/author"Cheong H.S."xsd:string
http://purl.uniprot.org/citations/20835340http://purl.uniprot.org/core/author"Kimm K."xsd:string
http://purl.uniprot.org/citations/20835340http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20835340http://purl.uniprot.org/core/name"Korean Diabetes J"xsd:string
http://purl.uniprot.org/citations/20835340http://purl.uniprot.org/core/pages"229-236"xsd:string
http://purl.uniprot.org/citations/20835340http://purl.uniprot.org/core/title"Polymorphisms of the reg1alpha gene and early onset type 2 diabetes in the korean population."xsd:string
http://purl.uniprot.org/citations/20835340http://purl.uniprot.org/core/volume"34"xsd:string
http://purl.uniprot.org/citations/20835340http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20835340
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