| http://purl.uniprot.org/citations/20839930 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20839930 | http://www.w3.org/2000/01/rdf-schema#comment | "This study investigated an association of SLCO (encoding organic anion-transporting polypeptides (OATP), 1B1, 1B3, and 2B1), ABCB1 (P-glycoprotein (P-gp)), ABCC2 multidrug resistance protein 2 (MRP2), and ABCG2 (breast cancer resistance protein (BCRP)) polymorphisms with fexofenadine enantiomer pharmacokinetics after an oral dose of fexofenadine (60 mg) in 24 healthy subjects. The area under the plasma concentration-time curve (AUC(0-24)) of S-fexofenadine, but not R-fexofenadine, was significantly lower in subjects with a SLCO2B1*1/*1 allele as compared to subjects with a *3 allele (p = 0.031). The AUC(0-24) of S-fexofenadine was significantly lower in subjects with a wild-type combination of SLCO2B1*1/*1/ABCB1 1236CC, SLCO2B1*1/*1/ABCB1 3435CC, SLCO2B1*1/*1/ABCC2 -24CC, and ABCB1 1236CC/3435CC/ABCC2 -24CC compared to other polymorphic genotypes (p = 0.010, 0.033, 0.022, and 0.036, respectively), whereas there was no difference in the AUC(0-24) between the SLCO1B1/1B3 plus ABCB1 and ABCC2 groups. The pharmacokinetic properties of S-fexofenadine are affected by a single polymorphism of SLCO2B1 in combination with several polymorphisms of ABCB1 C1236T, C3435T, and ABCC2 C-24T. However, the ABCG2 polymorphism was not associated with fexofenadine pharmacokinetics. These findings suggest that a combination of multiple transporters, including OATP, P-gp, and MRP2, reacts strongly to fexofenadine exposure in the small intestine and liver, resulting in different dispositions of both enantiomers."xsd:string |
| http://purl.uniprot.org/citations/20839930 | http://purl.org/dc/terms/identifier | "doi:10.3109/00498254.2010.515318"xsd:string |
| http://purl.uniprot.org/citations/20839930 | http://purl.uniprot.org/core/author | "Miura M."xsd:string |
| http://purl.uniprot.org/citations/20839930 | http://purl.uniprot.org/core/author | "Uno T."xsd:string |
| http://purl.uniprot.org/citations/20839930 | http://purl.uniprot.org/core/author | "Sunagawa S."xsd:string |
| http://purl.uniprot.org/citations/20839930 | http://purl.uniprot.org/core/author | "Yasui-Furukori N."xsd:string |
| http://purl.uniprot.org/citations/20839930 | http://purl.uniprot.org/core/author | "Kagaya H."xsd:string |
| http://purl.uniprot.org/citations/20839930 | http://purl.uniprot.org/core/author | "Akamine Y."xsd:string |
| http://purl.uniprot.org/citations/20839930 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20839930 | http://purl.uniprot.org/core/name | "Xenobiotica"xsd:string |
| http://purl.uniprot.org/citations/20839930 | http://purl.uniprot.org/core/pages | "782-789"xsd:string |
| http://purl.uniprot.org/citations/20839930 | http://purl.uniprot.org/core/title | "Influence of drug-transporter polymorphisms on the pharmacokinetics of fexofenadine enantiomers."xsd:string |
| http://purl.uniprot.org/citations/20839930 | http://purl.uniprot.org/core/volume | "40"xsd:string |
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