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http://purl.uniprot.org/citations/20847308http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20847308http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The vitamin D endocrine system is essential for calcium homeostasis, and low levels of vitamin D metabolites have been associated with cardiovascular disease risk. We hypothesized that DNA sequence variation in genes regulating vitamin D metabolism and signaling pathways might influence variation in coronary artery calcification (CAC).

Methods and results

We genotyped single-nucleotide polymorphisms (SNPs) in GC, CYP27B1, CYP24A1, and VDR and tested their association with CAC quantity, as measured by electron beam computed tomography. Initial association studies were carried out in a discovery sample comprising 697 Amish subjects, and SNPs nominally associated with CAC quantity (4 SNPs in CYP24A1, P=0.008 to 0.00003) were then tested for association with CAC quantity in 2 independent cohorts of subjects of white European ancestry (Genetic Epidemiology Network of Arteriopathy study [n=916] and the Penn Coronary Artery Calcification sample [n=2061]). One of the 4 SNPs, rs2762939, was associated with CAC quantity in both the Genetic Epidemiology Network of Arteriopathy (P=0.007) and Penn Coronary Artery Calcification (P=0.01) studies. In all 3 populations, the rs2762939 C allele was associated with lower CAC quantity. Metaanalysis for the association of this SNP with CAC quantity across all 3 studies yielded a P value of 2.9×10(-6).

Conclusions

A common SNP in the CYP24A1 gene was associated with CAC quantity in 3 independent populations. This result suggests a role for vitamin D metabolism in the development of CAC quantity."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.org/dc/terms/identifier"doi:10.1161/atvbaha.110.211805"xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Liu J."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Li M."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Shen H."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Wang X."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Mitchell B.D."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Hakonarson H."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Shuldiner A.R."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Rader D.J."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Hixson J.E."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Reilly M.P."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"O'Connell J.R."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Streeten E.A."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Post W."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Kardia S.L."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Yerges-Armstrong L.M."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Keating B.J."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Peyser P.A."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Jhun M.A."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Bielak L.F."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Koller D.L."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Mehta N.N."xsd:string
http://purl.uniprot.org/citations/20847308http://purl.uniprot.org/core/author"Sun Y.V."xsd:string
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