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http://purl.uniprot.org/citations/20847814http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20847814http://www.w3.org/2000/01/rdf-schema#comment"Background. Redox active substances (e.g., Thioredoxin-1, Macrophage Migration Inhibitory Factor) seem to be central hubs in the septic inflammatory process. Materials and Methods. Blood samples from patients with severe sepsis or septic shock (n = 15) were collected at the time of sepsis diagnosis (t0), and 24 (t24) and 48 (t48) hours later; samples from healthy volunteers (n = 18) were collected once; samples from postoperative patients (n = 28) were taken one time immediately after surgery. In all patients, we measured plasma levels of IL-6, TRX1 and MIF. Results. The plasma levels of MIF and TRX1 were significantly elevated in patients with severe sepsis or septic shock. Furthermore, TRX1 and MIF plasma levels showed a strong correlation (t0: r(sp) = 0.720, ρ = 0.698/t24: r(sp) = 0.771, ρ = 0.949). Conclusions. Proinflammatory/~oxidative and anti-inflammatory/~oxidative agents show a high correlation in order to maintain a redox homeostasis and to avoid the harmful effects of an excessive inflammatory/oxidative response."xsd:string
http://purl.uniprot.org/citations/20847814http://purl.org/dc/terms/identifier"doi:10.1155/2010/985614"xsd:string
http://purl.uniprot.org/citations/20847814http://purl.uniprot.org/core/author"Hofer S."xsd:string
http://purl.uniprot.org/citations/20847814http://purl.uniprot.org/core/author"Weitz J."xsd:string
http://purl.uniprot.org/citations/20847814http://purl.uniprot.org/core/author"Weigand M.A."xsd:string
http://purl.uniprot.org/citations/20847814http://purl.uniprot.org/core/author"Hoffmann U."xsd:string
http://purl.uniprot.org/citations/20847814http://purl.uniprot.org/core/author"Martin E.O."xsd:string
http://purl.uniprot.org/citations/20847814http://purl.uniprot.org/core/author"Bruckner T."xsd:string
http://purl.uniprot.org/citations/20847814http://purl.uniprot.org/core/author"Steppan J."xsd:string
http://purl.uniprot.org/citations/20847814http://purl.uniprot.org/core/author"Brenner T."xsd:string
http://purl.uniprot.org/citations/20847814http://purl.uniprot.org/core/author"Lichtenstern C."xsd:string
http://purl.uniprot.org/citations/20847814http://purl.uniprot.org/core/author"Rosenhagen C."xsd:string
http://purl.uniprot.org/citations/20847814http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20847814http://purl.uniprot.org/core/name"Mediators Inflamm"xsd:string
http://purl.uniprot.org/citations/20847814http://purl.uniprot.org/core/pages"985614"xsd:string
http://purl.uniprot.org/citations/20847814http://purl.uniprot.org/core/title"Redox responses in patients with sepsis: high correlation of thioredoxin-1 and macrophage migration inhibitory factor plasma levels."xsd:string
http://purl.uniprot.org/citations/20847814http://purl.uniprot.org/core/volume"2010"xsd:string
http://purl.uniprot.org/citations/20847814http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20847814
http://purl.uniprot.org/citations/20847814http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20847814
http://purl.uniprot.org/uniprot/#_P14174-mappedCitation-20847814http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20847814
http://purl.uniprot.org/uniprot/#_H9ZYJ2-mappedCitation-20847814http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20847814
http://purl.uniprot.org/uniprot/#_I4AY87-mappedCitation-20847814http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20847814
http://purl.uniprot.org/uniprot/#_P10599-mappedCitation-20847814http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20847814
http://purl.uniprot.org/uniprot/P14174http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20847814