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http://purl.uniprot.org/citations/20848146http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20848146http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20848146http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20848146http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the features of hepatitis B virus (HBV) basal core promoter/precore (BCP/PC) mutations and genotypes in a large number of mild/severe chronic hepatitis B (CHB-M/CHB-S), and acute-on-chronic liver failure (ACLF) patients and analyze the clinical implications of the virologic features.

Patients and methods

Sera of 793 (325 CHB-M, 170 CHB-S, and 298 ACLF) patients admitted to or who had visited Beijing 302 Hospital from January 2005 to December 2008 were collected and successfully amplified for the HBV BCP/PC and a 1225-bp-long S/Pol (nt 54-1278) gene regions. Biochemical and serological parameters and HBV DNA level were routinely performed. Viral DNA was extracted and subjected to a nested PCR. Genotypes/subgenotypes were determined based on complete genomic sequence or on analysis of the 1225-bp-long S/Pol-gene sequence. HBV genotyping was performed by direct PCR sequencing followed by molecular evolutionary analysis of the viral sequences. A P value of <0.05 (two-sided) was considered to be statistically significant.

Conclusions

Our findings suggest that CHB patients infected with BCP/PC mutant viruses are more susceptible to severe hepatitis and ACLF than those with the BCP/PC wild-type virus and that ACLF patients with PC mutant viruses have an increased risk of death. As such, the HBV PC mutation is a potential predictive indicator of ACLF outcome."xsd:string
http://purl.uniprot.org/citations/20848146http://purl.org/dc/terms/identifier"doi:10.1007/s00535-010-0315-4"xsd:string
http://purl.uniprot.org/citations/20848146http://purl.org/dc/terms/identifier"doi:10.1007/s00535-010-0315-4"xsd:string
http://purl.uniprot.org/citations/20848146http://purl.org/dc/terms/identifier"doi:10.1007/s00535-010-0315-4"xsd:string
http://purl.uniprot.org/citations/20848146http://purl.uniprot.org/core/author"Liu Y."xsd:string
http://purl.uniprot.org/citations/20848146http://purl.uniprot.org/core/author"Liu Y."xsd:string
http://purl.uniprot.org/citations/20848146http://purl.uniprot.org/core/author"Liu Y."xsd:string
http://purl.uniprot.org/citations/20848146http://purl.uniprot.org/core/author"Li X."xsd:string
http://purl.uniprot.org/citations/20848146http://purl.uniprot.org/core/author"Li X."xsd:string
http://purl.uniprot.org/citations/20848146http://purl.uniprot.org/core/author"Li X."xsd:string
http://purl.uniprot.org/citations/20848146http://purl.uniprot.org/core/author"Ren X."xsd:string
http://purl.uniprot.org/citations/20848146http://purl.uniprot.org/core/author"Ren X."xsd:string
http://purl.uniprot.org/citations/20848146http://purl.uniprot.org/core/author"Ren X."xsd:string
http://purl.uniprot.org/citations/20848146http://purl.uniprot.org/core/author"Xu D."xsd:string
http://purl.uniprot.org/citations/20848146http://purl.uniprot.org/core/author"Xu D."xsd:string
http://purl.uniprot.org/citations/20848146http://purl.uniprot.org/core/author"Xu D."xsd:string
http://purl.uniprot.org/citations/20848146http://purl.uniprot.org/core/author"Zhong Y."xsd:string
http://purl.uniprot.org/citations/20848146http://purl.uniprot.org/core/author"Zhong Y."xsd:string
http://purl.uniprot.org/citations/20848146http://purl.uniprot.org/core/author"Zhong Y."xsd:string
http://purl.uniprot.org/citations/20848146http://purl.uniprot.org/core/author"Wang L."xsd:string
http://purl.uniprot.org/citations/20848146http://purl.uniprot.org/core/author"Wang L."xsd:string
http://purl.uniprot.org/citations/20848146http://purl.uniprot.org/core/author"Wang L."xsd:string
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