| http://purl.uniprot.org/citations/20849876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20849876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20849876 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously identified a zebrafish mast cell (MC) lineage and now aim to determine if these cells function analogously in innate and adaptive immunity like their mammalian counterparts. Intraperitoneal (IP) injection of compound 48/80 or live Aeromonas salmonicida resulted in significant MC degranulation evident histologically and by increased plasma tryptase compared with saline-injected controls (p=0.0006, 0.005, respectively). Pre-treatment with ketotifen abrogated these responses (p=0.0004, 0.005, respectively). Cross-reactivity was observed in zebrafish to anti-human high-affinity IgE receptor gamma (FcɛRIγ) and IgE heavy chain-directed antibodies. Whole mount in situ hybridization on 7-day embryos demonstrated co-localization of cpa5, a MC-specific marker, with myd88, a toll-like receptor adaptor, and zebrafish FcɛRI subunit homologs. Zebrafish injected IP with matched dinitrophenyl-sensitized mouse (anti-DNP) IgE and DNP-BSA or trinitrophenyl-sensitized mouse (anti-TNP) IgE and TNP-BSA demonstrated increased plasma tryptase compared with mismatched controls (p=0.03, 0.010, respectively). These results confirm functional conservation and validate the zebrafish model as an in vivo screening tool for novel MC modulating agents."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.dci.2010.09.001"xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "Marshall J.S."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "Marshall J.S."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "Teh E.M."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "Teh E.M."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "Berman J.N."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "Berman J.N."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "Nasrallah G.K."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "Nasrallah G.K."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "Neuberg D.S."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "Neuberg D.S."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "Da'as S."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "Da'as S."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "Dobson J.T."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "Dobson J.T."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "Lin T.J."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "Lin T.J."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "McBride E.R."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/author | "McBride E.R."xsd:string |
| http://purl.uniprot.org/citations/20849876 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |