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http://purl.uniprot.org/citations/20851016http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20851016http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

Human T-cell lymphotropic virus type 1 (HTLV-1) infection leads to the risk of developing HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in less than 5% of cases. The mechanism of disease progression in HAM/TSP remains unknown. A significant role of certain human leukocyte antigen (HLA) genotypes in determining the risk of HAM/TSP has been reported in Japan, where the HLA-A*02 gene has been found to be associated with a lower HTLV-1 provirus load and with protection from HAM/TSP, whereas HLA-DRB1*0101 has been found to be associated with an increased susceptibility to HAM/TSP. The aim of the present case-control study was to investigate the HLA class I and class II allele distribution in HTLV-seropositive French Afro-Caribbean individuals, originating from the French West Indies.

Methods

Associations with HLA class I (A and B) and class II (DRB1 and DQB1) alleles were tested in 123 HAM/TSP patients and 85 asymptomatic HTLV-1 carriers. HLA typing was undertaken on genomic DNA extracted from peripheral blood leukocytes.

Results

In our cohort, no significant effect on either the risk of developing HAM/TSP or HTLV-1 provirus load was found for HLA class I or class II, including HLA-A*02 (p=0.43).

Conclusions

Our findings are in contrast to those in the Japanese population, however the literature on HLA associations in HTLV-1 infections across different populations over the past decade have reported conflicting results and this suggests strong ethnic disparities."xsd:string
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http://purl.uniprot.org/citations/20851016http://purl.uniprot.org/core/author"Bera O."xsd:string
http://purl.uniprot.org/citations/20851016http://purl.uniprot.org/core/author"Bellance R."xsd:string
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http://purl.uniprot.org/citations/20851016http://purl.uniprot.org/core/author"Belrose G."xsd:string
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http://purl.uniprot.org/citations/20851016http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20851016http://purl.uniprot.org/core/name"Int J Infect Dis"xsd:string
http://purl.uniprot.org/citations/20851016http://purl.uniprot.org/core/pages"e986-90"xsd:string
http://purl.uniprot.org/citations/20851016http://purl.uniprot.org/core/title"Absence of consistent association between human leukocyte antigen-I and -II alleles and human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis risk in an HTLV-1 French Afro-Caribbean population."xsd:string
http://purl.uniprot.org/citations/20851016http://purl.uniprot.org/core/volume"14"xsd:string
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