| http://purl.uniprot.org/citations/20851879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20851879 | http://www.w3.org/2000/01/rdf-schema#comment | "Progression of breast cancer is associated with remodeling of the extracellular matrix, often involving a switch from estrogen dependence to a dependence on EGF receptor (EGFR)/HER-2 and is accompanied by increased expression of the main binding protein for insulin-like growth factors (IGFBP-3). We have examined the effects of IGFBP-3 on EGF responses of breast epithelial cells in the context of changes in the extracellular matrix. On plastic and laminin with MCF-10A normal breast epithelial cells, EGF and IGFBP-3 each increased cell growth and together produced a synergistic response, whereas with T47D breast cancer cells IGFBP-3 alone had no effect, but the ability of EGF to increase cell proliferation was markedly inhibited in the presence of IGFBP-3. In contrast on fibronectin with MCF-10A cells, IGFBP-3 alone inhibited cell growth and blocked EGF-induced proliferation. With the cancer cells, IGFBP-3 alone had no effect but enhanced the EGF-induced increase in cell growth. The insulin-like growth factor-independent effects of IGFBP-3 alone on cell proliferation were completely abrogated in the presence of an EGFR, tyrosine kinase inhibitor, Iressa. Although IGFBP-3 did not affect EGFR phosphorylation [Tyr(1068)], it was found to modulate receptor internalization and was associated with activation of Rho and subsequent changes in MAPK phosphorylation. The levels of fibronectin and IGFBP-3 within breast tumors may determine their dependence on EGFR and their response to therapies targeting this receptor."xsd:string |
| http://purl.uniprot.org/citations/20851879 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.177311"xsd:string |
| http://purl.uniprot.org/citations/20851879 | http://purl.uniprot.org/core/author | "McIntosh J."xsd:string |
| http://purl.uniprot.org/citations/20851879 | http://purl.uniprot.org/core/author | "Jarrett C."xsd:string |
| http://purl.uniprot.org/citations/20851879 | http://purl.uniprot.org/core/author | "Perks C.M."xsd:string |
| http://purl.uniprot.org/citations/20851879 | http://purl.uniprot.org/core/author | "Holly J.M."xsd:string |
| http://purl.uniprot.org/citations/20851879 | http://purl.uniprot.org/core/author | "Foulstone E.J."xsd:string |
| http://purl.uniprot.org/citations/20851879 | http://purl.uniprot.org/core/author | "Winters Z.E."xsd:string |
| http://purl.uniprot.org/citations/20851879 | http://purl.uniprot.org/core/author | "Dennison G."xsd:string |
| http://purl.uniprot.org/citations/20851879 | http://purl.uniprot.org/core/author | "Frankow A."xsd:string |
| http://purl.uniprot.org/citations/20851879 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20851879 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20851879 | http://purl.uniprot.org/core/pages | "38788-38800"xsd:string |
| http://purl.uniprot.org/citations/20851879 | http://purl.uniprot.org/core/title | "IGFBP-3 can either inhibit or enhance EGF-mediated growth of breast epithelial cells dependent upon the presence of fibronectin."xsd:string |
| http://purl.uniprot.org/citations/20851879 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20851879 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20851879 |
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| http://purl.uniprot.org/uniprot/#_A6XND0-mappedCitation-20851879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20851879 |
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