| http://purl.uniprot.org/citations/20851988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20851988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20851988 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently, we isolated a new thiopeptide antibiotic, TP-1161, from the fermentation broth of a marine actinomycete typed as a member of the genus Nocardiopsis. Here we report the identification, isolation, and analysis of the TP-1161 biosynthetic gene cluster from this species. The gene cluster was identified by mining a draft genome sequence using the predicted structural peptide sequence of TP-1161. Functional assignment of a ∼16-kb genomic region revealed 13 open reading frames proposed to constitute the TP-1161 biosynthetic locus. While the typical core set of thiopeptide modification enzymes contains one cyclodehydratase/dehydrogenase pair, paralogous genes predicted to encode additional cyclodehydratases and dehydrogenases were identified. Although attempts at heterologous expression of the TP-1161 gene cluster in Streptomyces coelicolor failed, its identity was confirmed through the targeted gene inactivation in the original host."xsd:string |
| http://purl.uniprot.org/citations/20851988 | http://purl.org/dc/terms/identifier | "doi:10.1128/AEM.01442-10"xsd:string |
| http://purl.uniprot.org/citations/20851988 | http://purl.org/dc/terms/identifier | "doi:10.1128/aem.01442-10"xsd:string |
| http://purl.uniprot.org/citations/20851988 | http://purl.uniprot.org/core/author | "Engelhardt K."xsd:string |
| http://purl.uniprot.org/citations/20851988 | http://purl.uniprot.org/core/author | "Engelhardt K."xsd:string |
| http://purl.uniprot.org/citations/20851988 | http://purl.uniprot.org/core/author | "Zotchev S.B."xsd:string |
| http://purl.uniprot.org/citations/20851988 | http://purl.uniprot.org/core/author | "Zotchev S.B."xsd:string |
| http://purl.uniprot.org/citations/20851988 | http://purl.uniprot.org/core/author | "Degnes K.F."xsd:string |
| http://purl.uniprot.org/citations/20851988 | http://purl.uniprot.org/core/author | "Degnes K.F."xsd:string |
| http://purl.uniprot.org/citations/20851988 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20851988 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20851988 | http://purl.uniprot.org/core/name | "Appl. Environ. Microbiol."xsd:string |
| http://purl.uniprot.org/citations/20851988 | http://purl.uniprot.org/core/name | "Appl Environ Microbiol"xsd:string |
| http://purl.uniprot.org/citations/20851988 | http://purl.uniprot.org/core/pages | "7093-7101"xsd:string |
| http://purl.uniprot.org/citations/20851988 | http://purl.uniprot.org/core/pages | "7093-7101"xsd:string |
| http://purl.uniprot.org/citations/20851988 | http://purl.uniprot.org/core/title | "Isolation and characterization of the gene cluster for biosynthesis of the thiopeptide antibiotic TP-1161."xsd:string |
| http://purl.uniprot.org/citations/20851988 | http://purl.uniprot.org/core/title | "Isolation and characterization of the gene cluster for biosynthesis of the thiopeptide antibiotic TP-1161."xsd:string |
| http://purl.uniprot.org/citations/20851988 | http://purl.uniprot.org/core/volume | "76"xsd:string |
| http://purl.uniprot.org/citations/20851988 | http://purl.uniprot.org/core/volume | "76"xsd:string |
| http://purl.uniprot.org/citations/20851988 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20851988 |
| http://purl.uniprot.org/citations/20851988 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20851988 |
| http://purl.uniprot.org/citations/20851988 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20851988 |
| http://purl.uniprot.org/citations/20851988 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20851988 |