| http://purl.uniprot.org/citations/20855495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20855495 | http://www.w3.org/2000/01/rdf-schema#comment | "TAL1 (also known as SCL) is expressed in >40% of human T cell acute lymphoblastic leukemias (T-ALLs). TAL1 encodes a basic helix-loop-helix transcription factor that can interfere with the transcriptional activity of E2A and HEB during T cell leukemogenesis; however, the oncogenic pathways directly activated by TAL1 are not characterized. In this study, we show that, in human TAL1-expressing T-ALL cell lines, TAL1 directly activates NKX3.1, a tumor suppressor gene required for prostate stem cell maintenance. In human T-ALL cell lines, NKX3.1 gene activation is mediated by a TAL1-LMO-Ldb1 complex that is recruited by GATA-3 bound to an NKX3.1 gene promoter regulatory sequence. TAL1-induced NKX3.1 activation is associated with suppression of HP1-α (heterochromatin protein 1 α) binding and opening of chromatin on the NKX3.1 gene promoter. NKX3.1 is necessary for T-ALL proliferation, can partially restore proliferation in TAL1 knockdown cells, and directly regulates miR-17-92. In primary human TAL1-expressing leukemic cells, the NKX3.1 gene is expressed independently of the Notch pathway, and its inactivation impairs proliferation. Finally, TAL1 or NKX3.1 knockdown abrogates the ability of human T-ALL cells to efficiently induce leukemia development in mice. These results suggest that tumor suppressor or oncogenic activity of NKX3.1 depends on tissue expression."xsd:string |
| http://purl.uniprot.org/citations/20855495 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20100745"xsd:string |
| http://purl.uniprot.org/citations/20855495 | http://purl.uniprot.org/core/author | "Gerard D."xsd:string |
| http://purl.uniprot.org/citations/20855495 | http://purl.uniprot.org/core/author | "Romeo P.H."xsd:string |
| http://purl.uniprot.org/citations/20855495 | http://purl.uniprot.org/core/author | "Armstrong F."xsd:string |
| http://purl.uniprot.org/citations/20855495 | http://purl.uniprot.org/core/author | "Ballerini P."xsd:string |
| http://purl.uniprot.org/citations/20855495 | http://purl.uniprot.org/core/author | "Baruchel A."xsd:string |
| http://purl.uniprot.org/citations/20855495 | http://purl.uniprot.org/core/author | "Goardon N."xsd:string |
| http://purl.uniprot.org/citations/20855495 | http://purl.uniprot.org/core/author | "Ferri F."xsd:string |
| http://purl.uniprot.org/citations/20855495 | http://purl.uniprot.org/core/author | "Pflumio F."xsd:string |
| http://purl.uniprot.org/citations/20855495 | http://purl.uniprot.org/core/author | "Gault N."xsd:string |
| http://purl.uniprot.org/citations/20855495 | http://purl.uniprot.org/core/author | "Cayuela J.M."xsd:string |
| http://purl.uniprot.org/citations/20855495 | http://purl.uniprot.org/core/author | "Kusy S."xsd:string |
| http://purl.uniprot.org/citations/20855495 | http://purl.uniprot.org/core/author | "Gerby B."xsd:string |
| http://purl.uniprot.org/citations/20855495 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20855495 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/20855495 | http://purl.uniprot.org/core/pages | "2141-2156"xsd:string |
| http://purl.uniprot.org/citations/20855495 | http://purl.uniprot.org/core/title | "NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia."xsd:string |
| http://purl.uniprot.org/citations/20855495 | http://purl.uniprot.org/core/volume | "207"xsd:string |
| http://purl.uniprot.org/citations/20855495 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20855495 |
| http://purl.uniprot.org/citations/20855495 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20855495 |
| http://purl.uniprot.org/uniprot/P23771#attribution-EAFD19628F8D9BB87AC7A12120C1FC32 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20855495 |
| http://purl.uniprot.org/uniprot/Q86U70#attribution-D8E12640C509938997B8B3B2EEEAB2BA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20855495 |
| http://purl.uniprot.org/uniprot/Q86U70#attribution-EAFD19628F8D9BB87AC7A12120C1FC32 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20855495 |