| http://purl.uniprot.org/citations/20855553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20855553 | http://www.w3.org/2000/01/rdf-schema#comment | "Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women of reproductive age. Although genetic linkage analyses have demonstrated a susceptibility locus for PCOS mapping to the fibrillin-3 gene, the presence of fibrillin proteins in normal and polycystic ovaries has not been characterized. This study compared and contrasted fibrillin-1, -2, and -3 localization in normal and polycystic ovaries. Immunohistochemical stainings of ovaries from 21 controls and 9 patients with PCOS were performed. Fibrillin-1 was ubiquitous in ovarian connective tissue. Fibrillin-2 localized around antral follicles and in areas of folliculolysis. Fibrillin-3 was present in a restricted distribution within the specialized perifollicular stroma of follicles in morphological transition from primordial to primary type [transitional follicles (TFs)]. Fibrillin-1 and -2 stainings of PCOS ovaries were similar to those of the controls. However, in eight of the nine PCOS ovaries, there was a decrease in the number of TFs associated with fibrillin-3, including no staining in five PCOS samples; decreased number of fibrillin-3-associated TFs/mm(2) was confirmed by quantitative analysis. Our findings support a role for fibrillin-3 in the pathogenesis of PCOS and suggest fibrillin-3 may function in primordial to primary follicle transition. We propose that loss of fibrillin-3 during folliculogenesis may be an important factor in PCOS pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/20855553 | http://purl.org/dc/terms/identifier | "doi:10.1369/jhc.2010.956615"xsd:string |
| http://purl.uniprot.org/citations/20855553 | http://purl.uniprot.org/core/author | "Sakai L.Y."xsd:string |
| http://purl.uniprot.org/citations/20855553 | http://purl.uniprot.org/core/author | "Charbonneau N.L."xsd:string |
| http://purl.uniprot.org/citations/20855553 | http://purl.uniprot.org/core/author | "Jordan C.D."xsd:string |
| http://purl.uniprot.org/citations/20855553 | http://purl.uniprot.org/core/author | "Bohling S.D."xsd:string |
| http://purl.uniprot.org/citations/20855553 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20855553 | http://purl.uniprot.org/core/name | "J Histochem Cytochem"xsd:string |
| http://purl.uniprot.org/citations/20855553 | http://purl.uniprot.org/core/pages | "903-915"xsd:string |
| http://purl.uniprot.org/citations/20855553 | http://purl.uniprot.org/core/title | "Fibrillins in adult human ovary and polycystic ovary syndrome: is fibrillin-3 affected in PCOS?"xsd:string |
| http://purl.uniprot.org/citations/20855553 | http://purl.uniprot.org/core/volume | "58"xsd:string |
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