| http://purl.uniprot.org/citations/20855588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20855588 | http://www.w3.org/2000/01/rdf-schema#comment | "Sterol regulatory element-binding protein 2 (SREBP-2) transcription factor has been identified as a key protein in cholesterol metabolism through the transactivation of the LDL receptor and cholesterol biosynthesis genes. Here, we generated mice lacking microRNA (miR)-33, encoded by an intron of the Srebp2, and showed that miR-33 repressed the expression of ATP-binding cassette transporter A1 (ABCA1) protein, a key regulator of HDL synthesis by mediating cholesterol efflux from cells to apolipoprotein A (apoA)-I. In fact, peritoneal macrophages derived from miR-33-deficient mice showed a marked increase in ABCA1 levels and higher apoA-I-dependent cholesterol efflux than those from WT mice. ABCA1 protein levels in liver were also higher in miR-33-deficient mice than in WT mice. Moreover, miR-33-deficient mice had significantly higher serum HDL cholesterol levels than WT mice. These data establish a critical role for miR-33 in the regulation of ABCA1 expression and HDL biogenesis in vivo."xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1008499107"xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/author | "Hasegawa K."xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/author | "Kinoshita M."xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/author | "Kimura T."xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/author | "Nakamura T."xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/author | "Ono K."xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/author | "Horie T."xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/author | "Kita T."xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/author | "Nagao K."xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/author | "Iwanaga Y."xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/author | "Kuwabara Y."xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/author | "Horiguchi M."xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/author | "Marusawa H."xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/author | "Nishi H."xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/author | "Yokode M."xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/pages | "17321-17326"xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/title | "MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo."xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/20855588 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20855588 |
| http://purl.uniprot.org/citations/20855588 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20855588 |
| http://purl.uniprot.org/uniprot/#_Q9HCE1-mappedCitation-20855588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20855588 |