| http://purl.uniprot.org/citations/20857495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20857495 | http://www.w3.org/2000/01/rdf-schema#comment | "Zinc (Zn)-deficiency (ZD) is implicated in the pathogenesis of human oral-esophageal cancers. Previously, we showed that in ZD mice genetic deletion of cyclooxygenase-2 (Cox-2) enhances N-nitrosomethylbenzylamine-induced forestomach carcinogenesis. By contrast, Cox-2 deletion offers protection in Zn-sufficient (ZS) mice. We hypothesize that ZD activates pathways insensitive to COX-2 inhibition, thereby promoting carcinogenesis. This hypothesis is tested in a Cox-2(-/-) mouse tongue cancer model that mimics pharmacologic blockade of COX-2 by firstly examining transcriptome profiles of forestomach mucosa from Cox-2(-/-) and wild-type mice on a ZD vs. ZS diet, and secondly investigating the roles of identified markers in mouse forestomach/tongue preneoplasia and carcinomas. In Cox-2(-/-) mice exposed to the tongue carcinogen 4-nitroquinoline 1-oxide, dietary ZD elicited tongue/esophagus/forestomach carcinomas that were prevented by ZS. The precancerous ZD:Cox-2(-/-) vs. ZS:Cox-2(-/-) forestomach had an inflammatory signature with upregulation of the proinflammation genes S100a8 and S100a9. Bioinformatics analysis revealed overrepresentation of inflammation processes comprising S100a8/a9 and an nuclear factor (NF)-κB network with connectivity to S100A8. Immunohistochemistry revealed co-overexpression of S100A8, its heterodimeric partner S100A9, the receptor for advanced glycation end-products (RAGE), NF-κB p65, and cyclin D1, in ZD:Cox-2(-/-) forestomach/tongue preneoplasia and carcinomas, evidence for the activation of a RAGE-S100A8/A9 inflammatory pathway. Accumulation of p53 in these carcinomas indicated activation of additional inflammatory pathways. Zn-replenishment in ZD:Cox-2(-/-) mice reversed the inflammation and inhibited carcinogenesis. Thus, ZD activates alternative inflammation-associated cancer pathways that fuel tumor progression and bypass the antitumor effect of Cox-2 ablation. These findings have important clinical implications, as combination cancer therapy that includes Zn may improve efficacy."xsd:string |
| http://purl.uniprot.org/citations/20857495 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.25688"xsd:string |
| http://purl.uniprot.org/citations/20857495 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/20857495 | http://purl.uniprot.org/core/author | "Huang K."xsd:string |
| http://purl.uniprot.org/citations/20857495 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/20857495 | http://purl.uniprot.org/core/author | "Liu X.P."xsd:string |
| http://purl.uniprot.org/citations/20857495 | http://purl.uniprot.org/core/author | "Croce C.M."xsd:string |
| http://purl.uniprot.org/citations/20857495 | http://purl.uniprot.org/core/author | "Fong L.Y."xsd:string |
| http://purl.uniprot.org/citations/20857495 | http://purl.uniprot.org/core/author | "Farber J.L."xsd:string |
| http://purl.uniprot.org/citations/20857495 | http://purl.uniprot.org/core/author | "Wan S.G."xsd:string |
| http://purl.uniprot.org/citations/20857495 | http://purl.uniprot.org/core/author | "Smalley K.J."xsd:string |
| http://purl.uniprot.org/citations/20857495 | http://purl.uniprot.org/core/author | "Taccioli C."xsd:string |
| http://purl.uniprot.org/citations/20857495 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20857495 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/20857495 | http://purl.uniprot.org/core/pages | "331-345"xsd:string |
| http://purl.uniprot.org/citations/20857495 | http://purl.uniprot.org/core/title | "Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression."xsd:string |
| http://purl.uniprot.org/citations/20857495 | http://purl.uniprot.org/core/volume | "129"xsd:string |
| http://purl.uniprot.org/citations/20857495 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20857495 |
| http://purl.uniprot.org/citations/20857495 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20857495 |
| http://purl.uniprot.org/uniprot/#_A0A087WPT2-mappedCitation-20857495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20857495 |
| http://purl.uniprot.org/uniprot/#_Q3UMR6-mappedCitation-20857495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20857495 |
| http://purl.uniprot.org/uniprot/#_Q05769-mappedCitation-20857495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20857495 |
| http://purl.uniprot.org/uniprot/#_Q7TMV2-mappedCitation-20857495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20857495 |
| http://purl.uniprot.org/uniprot/A0A087WPT2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20857495 |