| http://purl.uniprot.org/citations/20859256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20859256 | http://www.w3.org/2000/01/rdf-schema#comment | "It remains uncertain how the DNA sequence of mammalian genes influences the transcriptional response to extracellular signals. Here, we show that the number of CREB-binding sites (CREs) affects whether the related histone acetyltransferases (HATs) CREB-binding protein (CBP) and p300 are required for endogenous gene transcription. Fibroblasts with both CBP and p300 knocked-out had strongly attenuated histone H4 acetylation at CREB-target genes in response to cyclic-AMP, yet transcription was not uniformly inhibited. Interestingly, dependence on CBP/p300 was often different between reporter plasmids and endogenous genes. Transcription in the absence of CBP/p300 correlated with endogenous genes having more CREs, more bound CREB, and more CRTC2 (a non-HAT coactivator of CREB). Indeed, CRTC2 rescued cAMP-inducible expression for certain genes in CBP/p300 null cells and contributed to the CBP/p300-independent expression of other targets. Thus, endogenous genes with a greater local concentration and diversity of coactivators tend to have more resilient-inducible expression. This model suggests how gene expression patterns could be tuned by altering coactivator availability rather than by changing signal input or transcription factor levels."xsd:string |
| http://purl.uniprot.org/citations/20859256 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2010.235"xsd:string |
| http://purl.uniprot.org/citations/20859256 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/20859256 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
| http://purl.uniprot.org/citations/20859256 | http://purl.uniprot.org/core/author | "Kasper L.H."xsd:string |
| http://purl.uniprot.org/citations/20859256 | http://purl.uniprot.org/core/author | "Brindle P.K."xsd:string |
| http://purl.uniprot.org/citations/20859256 | http://purl.uniprot.org/core/author | "Lerach S."xsd:string |
| http://purl.uniprot.org/citations/20859256 | http://purl.uniprot.org/core/author | "Jeevan T."xsd:string |
| http://purl.uniprot.org/citations/20859256 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20859256 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/20859256 | http://purl.uniprot.org/core/pages | "3660-3672"xsd:string |
| http://purl.uniprot.org/citations/20859256 | http://purl.uniprot.org/core/title | "CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation."xsd:string |
| http://purl.uniprot.org/citations/20859256 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/20859256 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20859256 |
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